Most osteopathic research has been technique, model, or protocol-driven which may not reflect actual clinical practice. Baseline health, mechanisms of injuries, and neuromusculoskeletal compensations are all unique per patient. An osteopathic research design that aligns with individualized patient care may better illustrate the role that OMM can play in health. Patient-specific, sequenced OMT by AGR (psOMT) addresses each patient's unique accrual of and response to somatic dysfunction throughout his or her body over time. To our knowledge, there have been no clinical studies looking at patient-specific, sequenced OMT by AGR and Quality of Life (QoL).


To assess the effects of patient-specific, sequenced OMT (psOMT) in various Quality of Life areas.


A noncomparative study was conducted on all consenting patients of Pikeville Medical Center's OMT clinic from April 2021 to May 2022. Participants were evaluated and treated with patient-specific, sequenced OMT (psOMT) by Area of Greatest Restriction (AGR). Participants were given 2 modified PROMIS 29 Quality of Life surveys to assess nine domains of QoL.


Participants who received psOMT showed statistically significant improvements in all 9 metrics of QoL (ρ<.001).


This study presents a paradigm for osteopathic medical research that honors each patient's unique accrual of and response to somatic dysfunction(SD) throughout their lifetime. This study suggests the following: 1) that SD may contribute to impairments in overall QoL, 2) that SD could represent a modifiable risk factor in general medical assessment, and therefore 3) that treatment of SD may contribute to improvements in QoL by relieving impairments to optimal physiologic function.

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