For most drugs, irrespective of their indications or mechanisms of actions, there is a recommended dose for adults and often multiple age- or weight-based recommended doses for children in the US Food and Drug Administration (FDA)–approved labeling, as seen in the package insert. For triazolam (Halcion) the usual recommended adult dose is 0.25 mg. Some drugs also have a recommended dose for elderly, medically compromised, or debilitated patients. For triazolam, this FDA-recommended dose is 0.125 mg. Many drugs also have an FDA maximum recommended dose (MRD) above which either there is insufficient data on safety and efficacy or else there is sufficient data to suggest that administering or prescribing above that limit markedly increases the risk of serious side effects such as overdose toxicity. For triazolam, the FDA's MRD is 0.5 mg. In fact, in the package insert, the FDA warns, “A dose of 0.5 mg should be used...
other| June 01 2014
When Can a Normal Dose Be an Overdose? Who Is at Risk?
Anesth Prog (2014) 61 (2): 45–46.
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Joel M. Weaver; When Can a Normal Dose Be an Overdose? Who Is at Risk?. Anesth Prog 1 June 2014; 61 (2): 45–46. doi: https://doi.org/10.2344/0003-3006-61.2.45
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