Sedation may minimize physiologic and behavioral stress responses. In our facility, the infusion rate of propofol is adjusted according to the bispectral index (BIS) in all cases of implant-related surgery; multivariate analysis of retrospective data enabled us to extract independent factors that affect the dose of propofol in sedation that are considered useful indicators for achieving adequate sedation. The study population comprised all patients undergoing implant-related surgery under intravenous sedation in Okayama University Hospital from April 2009 to March 2013. The infusion rate of propofol was adjusted to maintain the BIS value at 70–80. The outcome was the average infusion rate of propofol, and potential predictor variables were age, sex, body weight, treatment time, and amount of midazolam. Independent variables that affected the average infusion rate of propofol were extracted with multiple regression analysis. One hundred twenty-five subjects were enrolled. In the multiple regression analysis, female sex was shown to be significantly associated with a higher average infusion rate of propofol. Females may require a higher infusion rate of propofol than males to achieve adequate sedation while undergoing implant-related surgery.
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Summer 2016
Research Article|
June 01 2016
Female Patients Require a Higher Propofol Infusion Rate for Sedation
Shigeru Maeda, DDS, PhD;
Shigeru Maeda, DDS, PhD
*Department of Dental Anesthesiology, Okayama University Hospital, Okayama, Japan, and
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Yumiko Tomoyasu, DDS, PhD;
Yumiko Tomoyasu, DDS, PhD
†Department of Dental Anesthesiology and Special Care Dentistry, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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Hitoshi Higuchi, DDS, PhD;
Hitoshi Higuchi, DDS, PhD
*Department of Dental Anesthesiology, Okayama University Hospital, Okayama, Japan, and
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Yuka Honda, DDS;
Yuka Honda, DDS
*Department of Dental Anesthesiology, Okayama University Hospital, Okayama, Japan, and
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Minako Ishii-Maruhama, DDS, PhD;
Minako Ishii-Maruhama, DDS, PhD
*Department of Dental Anesthesiology, Okayama University Hospital, Okayama, Japan, and
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Takuya Miyawaki, DDS, PhD
Takuya Miyawaki, DDS, PhD
†Department of Dental Anesthesiology and Special Care Dentistry, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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Anesth Prog (2016) 63 (2): 67–70.
Citation
Shigeru Maeda, Yumiko Tomoyasu, Hitoshi Higuchi, Yuka Honda, Minako Ishii-Maruhama, Takuya Miyawaki; Female Patients Require a Higher Propofol Infusion Rate for Sedation. Anesth Prog 1 June 2016; 63 (2): 67–70. doi: https://doi.org/10.2344/0003-3006-63.2.67
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