Millions of patients take antidepressant medications in the United States for the treatment of depression or anxiety disorders. Some antidepressants are prescribed off-label to treat problems such as chronic pain, low energy, and menstrual symptoms. Antidepressants are a broad and expansive group of medications, but the more common drug classes include tricyclic antidepressants, selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, and monoamine oxidase inhibitors. A miscellaneous or “atypical” category covers other agents. Some herbal supplements that claim to have antidepressant activity will also be discussed. In Part I of this review, antidepressant pharmacology, adverse effects, and drug interactions with adrenergic agonists will be discussed. In part II, drug interactions with sedation and general anesthetics will be reviewed. Bleeding effects and serotonin syndrome implications in anesthetic practice will also be highlighted.
Skip Nav Destination
Article navigation
Winter 2017
CONTINUING EDUCATION IN HONOR OF NORMAN TRIEGER, DMD, MD|
December 01 2017
Anesthetic Considerations for Patients on Antidepressant Therapy—Part I
Mana Saraghi, DMD;
Mana Saraghi, DMD
*Director, Dental Anesthesiology Residency Program, Jacobi Medical Center, Bronx, New York
Search for other works by this author on:
Leonard R. Golden, MD;
Leonard R. Golden, MD
†Chairman, Department of Anesthesiology, Jacobi Medical Center Bronx, New York
Search for other works by this author on:
Elliot V. Hersh, DMD, MS, PhD
Elliot V. Hersh, DMD, MS, PhD
‡Professor, Pharmacology Director, Division of Pharmacology and Therapeutics, Department of Oral and Maxillofacial Surgery, University of Pennsylvania, Philadelphia
Search for other works by this author on:
Anesth Prog (2017) 64 (4): 253–261.
Citation
Mana Saraghi, Leonard R. Golden, Elliot V. Hersh; Anesthetic Considerations for Patients on Antidepressant Therapy—Part I. Anesth Prog 1 December 2017; 64 (4): 253–261. doi: https://doi.org/10.2344/anpr-64-04-14
Download citation file:
Sign in
Don't already have an account? Register
Client Account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Sign in via your Institution
Sign in via your InstitutionCiting articles via
The Physical Compatibility of Glycopyrrolate and Rocuronium
Austen L. Weeks, DDS, MA, John Sotos, DDS, Bryce Woolsey, DDS, William M. Johnston, MS, PhD, Bryant W. Cornelius, DDS, MBA, MPH
Involvement of α- and β-Adrenergic Receptors in Skeletal Muscle Blood Flow Changes During Hyper-/Hypocapnia in Anesthetized Rabbits
Kyotaro Koshika, DDS, PhD, Rumi Kaneko, DDS, Mai Shionoya, DDS, Kotaro Shimizu, DDS, Yuka Sendai, DDS, Nobutaka Matsuura, DDS, Yui Akiike, DDS, PhD, Tatsuya Ichinohe, DDS, PhD
Postoperative Epistaxis Following Dental Treatment With Nitrous Oxide/Oxygen Sedation
Ishfaq Khan, BDS, MFDS (RCPS), DSCD (RCSEd)
Cardiac Arrest Due to Pacing Failure From Pilsicainide Poisoning
Toshiyuki Kishimoto, DDS, PhD, Yoshiaki Takitani, DDS, PhD, Tomoka Ichikawa, Kaho Shiraishi, DDS, Hiroki Yamada, DDS, Shoko Oya, DDS, Makoto Kume, MD, PhD, Satoru Sakurai, DDS, PhD
Successful Premedication With Sublingual Midazolam Using a Suction Toothbrush
Jun Hirokawa, DDS, PhD, Naomi Kimata, DH