A bone resorptive agent extracted from the tissues surrounding orthodontically-treated teeth is purified using ultrafiltration and isoelectric focusing. A two-fold increase in release of 45Ca could be achieved with as little as 0.6 pg/ml of this material.

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Author notes

Dr. King is Professor and Chairman of the Department of Orthodontics at the University of Florida College of Dentistry in Gainesville. He holds a D.M.Sc. degree in Oral Biology from Harvard University, D.M.D. from Tuhs University, and a Certificate in Orthodontics from Harvard-Forsyth in Boston

Jayne Collier is a Research Associate at the University of Florida College of Dentistry. She holds an M.S. degree in Microbiology from Eastern Illinois University in Charleston