Recombinant human growth hormone (rhGH) increases stature when administered to non-GH-deficient idiopathic short statured children. The aims of this investigation were to determine pretreatment arch dimensions of short statured children (height ≥ 2 S.D. below mean for age) and to evaluate their response to rhGH administration by measuring arch-dimensional changes over 5 years of rhGH treatment. Dental casts of 28 short subjects (22 male, 6 female) and of age/gender-matched controls of normal stature were analyzed using a digital imaging system. Four measures of arch width and one of arch depth were calculated for each maxillary and mandibular cast. Subjects receiving orthodontic care were eliminated from the study at the initiation of treatment. Z-scores were calculated to allow for pooling of data.
Prior to rhGH treatment, all arch dimensions of the short statured subjects were smaller than the controls, with the exception of mandibular arch depth. Arch dimensions of the rhGH subjects did increase with the continued administration of rhGH. The control group also showed a significant trend for the arch dimensions to increase over time. The influence of rhGH treatment on arch dimensional changes over time remains equivocal based on the results of this investigation.
Krista A. Richey, DDS, MS, Assistant Professor, Departments of Community Dentistry and Pediatric Dentistry, Eastman Dental Center, Rochester, New York
James A. McNamara, Jr., DDS, MS, PhD, Professor, Department of Orthodontics and Pediatric Dentistry, School of Dentistry; Professor, Department of Anatomy and Cell Biology, School of Medicine; and Research Scientist, Center for Human Growth and Development, The University of Michigan, Ann Arbor
Janice J. Wilmot, DMD, MS, former Lecturer, Department of Orthodontics and Pediatric Dentistry, School of Dentistry, The University of Michigan, Ann Arbor. Currently in private practice in Lilburn, Georgia
Stanley M. Garn, PhD, Professor Emeritus of Nutrition, School of Public Health; Professor Emeritus of Anthropology; and Fellow Emeritus, Center for Human Growth and Development, The University of Michigan, Ann Arbor
Paul J. Loos, DDS, MS, Associate Professor, Department of Orthodontics and Pediatric Dentistry, School of Dentistry, The University of Michigan, Ann Arbor