Abstract
The palatally displaced canine (PDC) anomaly is a tooth malposition occurring in 1% to 3% of most populations. From the results of family studies, the PDC phenotype appears to be under strong genetic influence. In this study we report monozygotic (MZ) twin girls with bilateral PDC expression. The finding of PDC anomaly in MZ twins—to our knowledge, the first such published case—lends further support to evidence of genetic control of the PDC anomaly.
INTRODUCTION
The maxillary canine tooth shows an unusual predisposition for palatal displacement and impaction. In 1% to 3% of most populations,1–4 the canine takes an ectopic developmental pathway palatally and is discovered impacted in the palatal bone or unerupted under the thick palatal mucosa. The palatally displaced canine (PDC) anomaly is found twice as often in females than in males and is approximately five times more prevalent in people of European descent than in Asians.5 Although found uncommonly in the general population, PDC is observed frequently in orthodontic samples.
From a growing body of scientific evidence, the PDC anomaly appears to have genetic origins. Mendelian family studies,6–10 epidemiological findings,11 and meta-analysis5 of earlier reports strongly suggest that PDC is one of a constellation of genetically controlled dental anomalies—like tooth agenesis and tooth-size reduction—often seen occurring in combination and in families. Current research findings suggest that genes associated with hypodontia of posterior teeth—molars and premolars—may be associated with the genesis of PDC.12
Thus, expression of PDC in a set of monozygotic (MZ) twins, although previously unreported in the scientific literature to our knowledge, would be an expected occurrence. Other discrete anomalies of tooth position, such as transposition of maxillary canine–first premolar and transposition of mandibular lateral incisor–canine, have been noted in identical twins.13,14 In this study we report MZ twin girls with bilateral PDC anomalies.
CASE REPORT
MZ female twins of 10.7 years of age (ES and DS) were presented for orthodontic treatment at the University of Catania dental clinics in southern Italy. The parents' chief complaint was protrusion of the maxillary and mandibular front teeth. Clinical examination revealed that the prepubertal Caucasian girls were in the late mixed dentition with similar Angle Class I malocclusions. Each had an overjet of 4.0 mm, an overbite of 3.5 mm, and coincident dental and facial midlines (Figure 1a,b). No arch length deficiencies were noted. The permanent teeth measured within the normal range of size, when compared with Caucasian odontometric values, and concordance of tooth size between the twins was discernable (Table 1).
(a) MZ twin ES: initial photographs, at age 10.7 years. (b) MZ twin DS: initial photographs, at age 10.7 years
(a) MZ twin ES: initial photographs, at age 10.7 years. (b) MZ twin DS: initial photographs, at age 10.7 years
Monozygotic Twins with PDC Anomaly: Mesiodistal (MD) Crown Diameters of Permanent Teeth (in mm to the nearest 0.5 mm)
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Panoramic dental radiographs showed mesioangular palatal development of both unerupted maxillary permanent canines for each twin (Figure 2a,b). In twin ES a more severe left-side developing PDC phenotype was apparent. In twin DS a more severe right-side developing PDC phenotype was evident. Another notable radiographic feature was marked mesioangular ectopic eruption of the mandibular second molars in the case of each twin, despite the adequacy of arch space.
Panoramic radiographs, initial, at age 10.7 years. (a) MZ twin ES, (b) MZ twin DS
Panoramic radiographs, initial, at age 10.7 years. (a) MZ twin ES, (b) MZ twin DS
For both 10.7-year-old girls, interceptive treatment of the developing bilateral PDC condition was attempted according to the recognized method, extraction of the maxillary deciduous canine teeth.15–18 The children were then observed over a 15-month period, with only a facebow headgear in place for part of the time on the maxillary first molars to assure that no space loss occurred after extraction. Panoramic dental radiographs taken again at the age of 12 years indicated partial success of the PDC interception procedure: twin ES showed relatively normal eruption of the right maxillary canine and an impacted palatal displacement of the left one, whereas twin DS showed the left maxillary canine in nearly normal position and the maxillary right canine impacted palatally (Figure 3a,b). Thus, at this point, a mirror imaging of palatally embedded canines was noted between the MZ twin girls.
Panoramic radiographs, progress, at age 12.0 years. (a) MZ twin ES, (b) MZ twin DS
Panoramic radiographs, progress, at age 12.0 years. (a) MZ twin ES, (b) MZ twin DS
Six months later, at age 12.5 years, corrective orthodontic treatment was planned for the twins, commencing with surgical exposure of the unerupted PDCs.
DISCUSSION
Since Francis Galton's classic paper19 of 1875, twin studies have been viewed as an ideal way to evaluate the interaction between genetic (nature) and environmental (nurture) influences on a particular phenotype, including dentofacial variations.20 Biologically, twinning results from a single fertilized ovum; so MZ twins are identical genetically. The chance that both MZ twins would express the same uncommon abnormality or condition as a random happening is highly unlikely.* Thus, it is reasonable that concordance of expression of an anomaly such as PDC in MZ twins may be a function or malfunction programmed into their genotype. To our knowledge, this is the first report of an unambiguous PDC anomaly in MZ twins.
The maxillary lateral incisors were present, well aligned, and of normal shape and size in both girls in this report. In fact, the mesiodistal crown measurements of all the erupted permanent teeth of the twins (Table 1) were uniformly average when compared with normative tooth-size data for Caucasians.21 Therefore, the empirical notion22 that PDC occurrence is under the mechanical control of a small, conical (peg shaped), or missing adjacent lateral incisor is not supported in this study.
The marked mesioangular malposition of the mandibular second molars observed in both girls may be worthy of further investigation. Earlier studies by Hoffmeister,23 Bjerklin et al,24 and Baccetti25 have identified ectopic eruption of molars occurring as part of dental anomaly patterns. In addition, signs of enamel hypoplasia seen on some maxillary molars of both twins may be linked biologically to these related patterns of abnormal dental conditions.25
REFERENCES
*Using a prevalence rate of 2% for PDC, the probability that PDC would occur randomly in both members of a MZ twin pair would be one in 2500.
Author notes
Corresponding author: Sheldon Peck, DDS, 1615 Beacon Street, Newton, MA 02468-1507 ([email protected])