Listed below are questions based on articles that appeared in last month's print edition of the Archives. Registered continuing medical education participants should use the October 2004 answer sheet to answer these questions.

  • 1. Gastric MALT lymphoma affects mainly young adult males.

     True or False?

    (from One Patient, Two Lymphomas—Tang et al)

  • 2. In regard to chronic myeloid leukemia (CML):

    • a. imatinib produced a complete hematologic response in 88% and a cytogenetic response in 49% of patients in chronic phase who did not respond to interferon alfa

    • b. the most common mechanism for relapse is mutations within the Bcr-Abl kinase domain

    • c. clonal cytogenetic evolution was not detected in CML patients treated with imatinib

    • d. a and b

    • e. a and c

      (from Progression of Chronic Myeloid Leukemia to Blast Crisis During Treatment With Imatinib Mesylate—Xu et al)

  • 3. The majority of urachal carcinomas are squamous cell carcinomas.

     True or False?

    (from An Isolated Vertebral Metastasis of Urachal Adenocarcinoma—Taylor et al)

  • 4. Merkel cells:

    • a. are found in adult epidermis and in the outer sheath of hair follicles

    • b. are highlighted with cytokeratins 8 and 18

    • c. are extremely rare in malignant tumors with possible follicular differentiation

    • d. a and b

    • e. a and c

      (from Chondroid Syringoma—Salama et al)

  • 5. Antipyretic medication reduces the overall incidence of febrile nonhemolytic transfusion reaction, and this reduction is more pronounced with platelets than with red blood cells.

     True or False?

    (from Febrile Nonhemolytic Transfusion Reactions—Ezidiegwu et al)

  • 6. Invasive breast carcinomas measuring 0.1 cm or less identified in core needle biopsy specimens:

    • a. most often represent a limited sample of a larger, more significant tumor

    • b. have the same clinical significance as invasive breast carcinomas measuring 0.1 cm or less identified in open biopsy and excision specimens

    • c. very often are associated with ductal carcinoma in situ and atypical hyperplasias

    • d. a and b

    • e. a and c

      (from Minimal (≤0.1 cm) Invasive Carcinoma in Breast Core Needle Biopsies— Renshaw)