Edited by Gary J. Schiller, 342 pp, with illus, Totowa, NJ, Humana Press Inc, 2003.

Chronic Leukemias and Lymphomas: Biology, Pathophysiology, and Clinical Management is a multiauthored text that provides an up-to-date overview of a biologically diverse group of hematologic neoplasms characterized by a relatively indolent natural history. The goal of this book, as stated in the preface, is to describe the unique features of these chronic hematologic neoplasms and to provide insights into their clinical manifestations and new treatment.

This 342-page book contains 12 comprehensive reviews (chapters) that are very well written and well referenced. The first review is titled “Chronic Leukemias: History, Epidemiology, and Risk Factors,” which provides a concise overview of chronic lymphocytic leukemia and chronic myelogenous leukemia. This chapter is followed by 11 reviews covering chronic lymphocytic leukemia, hairy cell leukemia, prolymphocytic leukemias, chronic myeloid leukemia, Sézary syndrome, large granular lymphocyte proliferative diseases, myeloproliferative syndromes, advances in the biology and treatment of multiple myeloma, low-grade lymphoma, aggressive large cell lymphomas, and Hodgkin disease.

The information in the text is well referenced and up to date. An extensive collection of current references concludes each chapter and provides additional information about articles pertaining to the subjects discussed in each chapter. The major strength of this book is its summarization of recent advances in both basic biology and the management of myeloproliferative disorders, low-grade lymphomas, and chronic leukemias. The various authors of the chapters place special emphasis on discussion of the novel therapeutic approaches for chronic hematologic neoplasms, such as purine nucleoside analogs for chronic lymphocytic leukemias, monoclonal antibodies for follicular lymphomas, and STI-571 (Gleevec) for chronic myelogenous leukemia. The mechanisms of disease progression in chronic hematologic neoplasms are well discussed in this book.

The book includes clear tables and figures that summarize important concepts, diagnostic criteria, chemotherapy regimens, clinical epidemiologic data, and results derived from recent clinical trails. Some chapters provide black-and-white microphotographs that illustrate the morphologic features of the diseases. In addition, evidence-based information is presented to address certain controversial issues such as the role of human herpesvirus-8 in the pathogenesis of the multiple myeloma.

Overall, this book is very well written and provides concise but comprehensive reviews of recent advances in chronic hematologic neoplasms. It would be an excellent addition to the libraries of hematologists, oncologists, and hematopathologists. It would also be a good resource for individuals with research interests in malignant hematologic neoplasms.