Listed below are questions based on articles that appeared in last month's print edition of the Archives. Registered continuing medical education participants should use the April 2004 answer sheet to answer these questions.

  • 1. Collision tumors are composed of 2 histologically distinct neoplasms that:

    • a. have clear areas of transition between the 2 tumors

    • b. intermix with one another

    • c. occur when carcinoma metastasizes to lymph nodes that contain lymphoma

    • d. a and c

    • e. b and c

      (from Collision Metastasis of Prostatic and Colonic Adenocarcinoma—Wade et al)

  • 2. The microscopic examination of cytologic preparations is more sensitive in detecting high-grade cervical lesions than DNA testing for human papillomavirus.

    True or False?

    (from Can Human Papillomavirus DNA Testing Substitute for Cytology in the Detection of High-Grade Cervical Lesions?—Lee et al)

  • 3. The pathogenesis of progressive multifocal leukoencephalopathy that develops in 4% to 8% of human immunodeficiency virus 1 (HIV-1)–infected patients involves:

    • a. cross-communication between HIV-1 and a polyomavirus, JC virus (JCV) through the regulatory protein Tat

    • b. the activation of latent cytomegalovirus infection

    • c. modulation of the Smad family of transcription factors by transforming growth factor β1 (TGF-β1)

    • d. a and c

    • e. b and c

      (from Evidence for Involvement of Transforming Growth Factor β1 Signaling Pathway in Activation of JC Virus in Human Immunodeficiency Virus 1–Associated Progressive Multifocal Leukoencephalopathy—Enam et al)

  • 4. A serum prostate-specific antigen (PSA) level of 0.2 ng/mL following radical prostatectomy constitutes definitive evidence to treat tumor recurrence immediately.

    True or False?

    (from How Sensitive Is a Prostate-Specific Antigen Measurement?—Bock & Klee)

  • 5. Extramedullary myeloid cell tumors (EMCT):

    • a. are most common in the gastrointestinal tract

    • b. usually present as discrete tumor masses when involving the testes

    • c. may also present as acute hemorrhage with diffuse intratubular infiltration

    • d. a and c

    • e. b and c

      (from Testicular Extramedullary Myeloid Cell Tumor—Rawal et al)

  • 6. The detection of loss of heterozygosity of tumor suppressor genes (eg, p53, p16) in odontogenic keratocysts would indicate a potential aggressive clinical behavior.

    True or False?

    (from Molecular Analysis to Demonstrate That Odontogenic Keratocysts Are Neoplastic—Agaram et al)