Listed below are questions based on articles that appeared in last month's print edition of the Archives. Registered continuing medical education participants should use the May 2004 answer sheet to answer these questions.

  • 1. Definite criteria for malignancy in endocrine pancreatic tumors do not rely on classic features such as nuclear pleomorphism, prominent nucleoli, perineural infiltration or vascular invasion.

     True or False?

    (from Cellular Proliferative Fraction Measured With Topoisomerase IIα Predicts Malignancy in Endocrine Pancreatic Tumors—Diaz-Rubio et al)

  • 2. Gastrointestinal stromal tumors may be immunonegative for CD117.

     True or False?

    (from Role of PTEN in Gastrointestinal Stromal Tumor Progression—Ricci et al)

  • 3. Amebic meningoencephalitis may present in:

    • a. young healthy adults and children with a fulminant course, resulting in death within a week after exposure

    • b. immunodeficient (eg, AIDS) or immunosuppressed (eg, organ transplant) patients with a prolonged clinical course

    • c. people exposed to ameba-containing soil, with the organisms entering via the skin or respiratory tract

    • d. a and b

    • e. a, b, and c

      (from Balamuthia mandrillaris Meningoencephalitis in an Immunocompetent Patient—Jung et al)

  • 4. The World Health Organization defined bronchioloalveolar carcinomas in 1999 as tumors with a pure lepidic (classic) growth pattern and no invasion.

     True or False?

    (from Immunohistochemical Analysis of Lung Carcinomas With Pure or Partial Bronchioloalveolar Differentiation—Sarantopoulos et al)

  • 5. Inlet patch is a term used to designate a congenital anomaly of the cervical esophagus that:

    • a. consists of intestinal-type mucosa

    • b. is present in most cases of Barrett esophagus

    • c. consists of gastric-type mucosa

    • d. b and c

    • e. a and c

      (from Inlet Patch—Tang et al)

  • 6. Research findings suggest that all Rh D-negative women bearing Rh D-positive babies should have fetomaternal hemorrhage screening and subsequent quantitation if the screen is positive.

     True or False?

    (from Three Cases of Massive Fetomaternal Hemorrhage Presenting Without Clinical Suspicion—Pourbabak et al)