Listed below are questions based on articles that appeared in last month's print edition of the Archives. Registered continuing medical education participants should use the November 2006 answer sheet to answer these questions.
1. Significant differences in the expression of MUC1 and MUC2 were observed between benign and malignant neoplastic endocervical lesions.
True or False?
(from Mucinous Expression in Benign and Neoplastic Glandular Lesions of the Uterine Cervix—Baker et al)
2. In discussing subinvolution, which of the following statements is false?
a. its most common reported timeline for presentation is within the 4th week after delivery
b. it has been reported to cause bleeding after induced abortion and after molar pregnancy evacuation
c. it may be a manifestation of an abnormal interaction between fetal-derived trophoblasts and maternal tissue
d. its microscopic features include lack of internal elastic lamina duplication and partial or complete absence of a true endothelial lining
e. its diagnosis should be rendered only in the appropriate clinical setting; specifically, secondary (delayed) postpartum bleeding
(from Subinvolution of the Placental Site as an Anatomic Cause of Postpartum Uterine Bleeding—Weydert & Benda)
3. A recent study found that CD34 was not expressed by any desmoid tumors but showed high reactivity with 8 of 11 solitary fibrous tumors, including both histologically benign and malignant solitary fibrous tumors.
True or False?
(from Pleuropulmonary Desmoid Tumors—Andino et al)
4. Which of the following findings in a study of 34 cases of lymphoma involving the pleura is true?
a. pleural lymphomas more often involve the right side
b. most patients with pleural lymphoma had de novo disease, with no history of lymphoma
c. cytologic examination of pleural fluid had a false-negative rate of almost 50%
d. among 29 patients whose lymphomas could be classified using the World Health Organization classification, follicular lymphoma was most common
e. in the 2 cases of small lymphocytic lymphoma/chronic lymphocytic leukemia, the tumor cells were negative for CD5 and CD20, and were positive for cyclin D1
(from Lymphomas Involving the Pleura—Vega et al)
5. The most important prognostic factor in pediatric soft tissue sarcomas is histologic type.
True or False?
(from Grading of Soft Tissue Sarcomas—Coindre)
6. Which of the following statements concerning rhabdomyosarcomas is false?
a. they comprise the most common single soft tissue sarcomas among children and adolescents
b. they typically present as bulging, infiltrative, growing soft tissue masses that may be fungating when they present in such external locations as the conjunctiva and vagina
c. embryonal rhabdomyosarcoma cells tend to have oblong shapes with oval nuclei and relatively bland chromatin
d. pleomorphic rhabdomyosarcomas comprise high-grade sarcomas composed of large, interlacing spindle cells containing irregular, hyperchromatic nuclei and numerous mitoses
e. patients with metastatic rhabdomyosarcoma with the PAX7-FKHR fusion gene appear to have a substantially worse prognosis than those patients with the PAX3-FKHR fusion gene
(from Rhabdomyosarcomas in Adults and Children—Parham & Ellison)