To the Editor.—I read with interest the excellent and informative review article by Kamel-Reid et al1  on the “Validation of KRAS Testing for Anti-EGFR Therapeutic Decisions for Patients With Metastatic Colorectal Carcinoma.” The review article is certainly an excellent guide for practicing pathologists in this molecular era. However, I observed an error in the equations given for analytic sensitivity (p 30) and analytic specificity (p 31) in the article.

The correct equation for analytic sensitivity is [True-positives/(True-positives + False-negatives)] × 100% NOT [True-positives/(True-positives + False-positives)] × 100%, as indicated in the article.

Similarly, the correct equation for analytic specificity is [True-negatives/(True-negatives + False-positives)] × 100% NOT [True-negatives/(True-positives + False-positives)] × 100%, as stated in the article.

1
Kamel-Reid
S
,
Zhang
T
,
Persons
DL
,
Nikiforova
MN
,
Halling
KC
;
Molecular Oncology Resource Committee of the College of American Pathologists. Validation of KRAS testing for anti-EGFR therapeutic decisions for patients with metastatic colorectal carcinoma
.
Arch Pathol Lab Med
.
2012
;
136
(
1
):
26
32
.

Editor's Note: An erratum listing the correct formulas for determining analytic sensitivity and analytic specificity has been published.