Every autumn, the Department of Pathology at the University of Michigan (UM, in Ann Arbor) organizes a case-based continuing medical education (CME) conference directed toward an audience of community and academic pathologists and trainees. The intent is to provide up-to-date, cutting-edge, and practical information for the practicing pathologist. Last year, the 3-day conference took place in Ann Arbor on September 27–29, 2017. Although we invited 3 excellent outside speakers, the meeting was primarily “home grown” with the majority of case studies and interactive break-out sessions presented by UM faculty. With gracious support from the editorial staff of Archives of Pathology & Laboratory Medicine, we put forth 9 review articles based on topics presented at the conference. The manuscripts are/will be published in 2 separate issues: the first 5 papers in this issue and 4 more in the December issue.
This issue contains 5 review articles dedicated to head and neck, gastrointestinal and orthopedic pathology, and cytopathology. The article by Weindorf, Brown, McHugh, and Udager focuses on sinonasal papillomas and carcinomas. In this review, the authors present a very thorough yet concise review and update on the pathobiology of these lesions, including important potentially diagnostic and targetable molecular signatures, several of which were first identified by the authors. The article by Fang and Shi is a very up-to-date and thorough review of pancreatic neuroendocrine tumors including the latest World Health Organization classification system, immunomorphologic and molecular features, current treatment strategies, and differential diagnosis. Authors Hall and Appelman present an excellent review of autoimmune gastritis, including its pathogenesis, clinical symptoms, and histopathology. Autoimmune gastritis can be very challenging to diagnose in a mucosal biopsy, thus greater knowledge of its etiology and histopathology as detailed by the authors can prevent misdiagnosis that may result in inadequate patient management. Wang and Lucas review the salient clinical, radiographic, and immunomorphologic features, and differential diagnosis of primary leiomyosarcoma of bone, a challenging entity to diagnose owing to its rarity and broad histologic spectrum. Finally, Cantley presents a very timely review of the cytopathologic features of basaloid salivary gland lesions, including a review of the Milan System for reporting salivary gland cytopathology.
Next month's issue of Archives will contain 4 review papers on genitourinary, breast, and soft tissue pathology. Taylor, Spratt, Dhanasekaran, and Mehra present a very current review and update of the categorization of renal tumors including state-of-the-art information on novel biomarkers. McMullen, Zoumberos, and Kleer review the classification, immunomorphologic and clinical features, and differential diagnostic considerations of the 5 subtypes of metaplastic breast carcinoma. In addition, the authors report recent discoveries from their laboratory on its molecular pathobiology. East, Carter, and Sciallis report the immunomorphologic features of a recently described entity: cellular spindled histiocytic pseudotumor, a form of mammary fat necrosis with broad differential diagnostic considerations. Finally, Carter and Patel present an up-to-date review of the rare entity, ossifying fibromyxoid tumor. In addition to detailed descriptions of its immunomorphologic features and differential diagnoses, the authors provide a thorough update on its molecular biology.
We hope you enjoy these articles.
Lauren B. Smith, MD Lauren B. Smith, MD, is a professor in the Department of Pathology at the University of Michigan specializing in hematopathology. She completed her medical school (MD 2002), residency (anatomic pathology/clinical pathology), and hematopathology fellowship at the University of Michigan (Ann Arbor). She is director of Hematopathology and director of the Ethics Path of Excellence in the University of Michigan Medical School. She is 1 of 7 clinical ethicists at the University of Michigan. Dr Smith has authored more than 50 articles and book chapters. Her areas of interest are clinical ethics and lymphoma.
Lauren B. Smith, MD Lauren B. Smith, MD, is a professor in the Department of Pathology at the University of Michigan specializing in hematopathology. She completed her medical school (MD 2002), residency (anatomic pathology/clinical pathology), and hematopathology fellowship at the University of Michigan (Ann Arbor). She is director of Hematopathology and director of the Ethics Path of Excellence in the University of Michigan Medical School. She is 1 of 7 clinical ethicists at the University of Michigan. Dr Smith has authored more than 50 articles and book chapters. Her areas of interest are clinical ethics and lymphoma.
Maria Westerhoff, MD Maria Westerhoff, MD, graduated from the Guaranteed Professional Program Admissions and Honors College of University of Illinois-Chicago and received her medical degree in 2006. She then completed her pathology residency and fellowship in gastrointestinal and hepatic pathology at the University of Chicago in 2011. She was a faculty member at the University of Washington in Seattle from 2011, where she was promoted to associate professor in 2016. She joined the University of Michigan in 2017. Dr Westerhoff is the treasurer of the Arthur Purdy Stout Surgical Pathology Society, past chair of the education committee of the Rodger Haggitt Gastrointestinal Pathology Society, a member of the Laennec Society, and a member of the congress scientific advisory board of the World Organization for Specialized Studies on Diseases of the Esophagus (OESO).
Maria Westerhoff, MD Maria Westerhoff, MD, graduated from the Guaranteed Professional Program Admissions and Honors College of University of Illinois-Chicago and received her medical degree in 2006. She then completed her pathology residency and fellowship in gastrointestinal and hepatic pathology at the University of Chicago in 2011. She was a faculty member at the University of Washington in Seattle from 2011, where she was promoted to associate professor in 2016. She joined the University of Michigan in 2017. Dr Westerhoff is the treasurer of the Arthur Purdy Stout Surgical Pathology Society, past chair of the education committee of the Rodger Haggitt Gastrointestinal Pathology Society, a member of the Laennec Society, and a member of the congress scientific advisory board of the World Organization for Specialized Studies on Diseases of the Esophagus (OESO).
David R. Lucas, MD After completing his anatomic pathology residency at Wayne State University (WSU) in Detroit, Michigan, David R. Lucas, MD, did bone and soft tissue and surgical pathology fellowships at the Mayo Clinic in Rochester, Minnesota (1991–1993). He then accepted a faculty position at WSU and worked there until 2003. He was course director for the sophomore connective tissue unit at WSU (1995–2003) and director of Immunohistochemistry at the Detroit Medical Center (2000–2003). Dr Lucas joined the faculty of the University of Michigan (Ann Arbor) (2003) and was promoted to professor (2006). He served as director of Immunohistochemistry (2006–2010), director of Surgical Pathology (2010–2015), program director of the surgical pathology fellowship (2010–2015), and director of Anatomic Pathology (2015–2019). In 2016 he was endowed with the A. James French Professorship in Anatomic Pathology. He currently serves as the director of Bone and Soft Tissue Pathology. He is past president of the Association of Directors of Anatomic and Surgical Pathology. Dr Lucas has published broadly on bone and soft tissue tumors and has presented at various national and international venues.
David R. Lucas, MD After completing his anatomic pathology residency at Wayne State University (WSU) in Detroit, Michigan, David R. Lucas, MD, did bone and soft tissue and surgical pathology fellowships at the Mayo Clinic in Rochester, Minnesota (1991–1993). He then accepted a faculty position at WSU and worked there until 2003. He was course director for the sophomore connective tissue unit at WSU (1995–2003) and director of Immunohistochemistry at the Detroit Medical Center (2000–2003). Dr Lucas joined the faculty of the University of Michigan (Ann Arbor) (2003) and was promoted to professor (2006). He served as director of Immunohistochemistry (2006–2010), director of Surgical Pathology (2010–2015), program director of the surgical pathology fellowship (2010–2015), and director of Anatomic Pathology (2015–2019). In 2016 he was endowed with the A. James French Professorship in Anatomic Pathology. He currently serves as the director of Bone and Soft Tissue Pathology. He is past president of the Association of Directors of Anatomic and Surgical Pathology. Dr Lucas has published broadly on bone and soft tissue tumors and has presented at various national and international venues.