Context.—

A number of fibro-osseous and osteocartilaginous lesions, especially common in the small bones of hand and feet, pose a diagnostic challenge and have historically been thought to be reactive lesions. However, modern molecular techniques when supplementing clinical, radiographic, and histologic evaluation suggest they may, in fact, be neoplasms.

Objective.—

To review the clinical presentation and histopathologic, molecular, and radiologic features of selective bone lesions, focusing most specifically on subungual exostosis, florid reactive periostitis, and bizarre periosteal osteochondromatous proliferation.

Data Sources.—

Literature review and personal experience are the source of this review.

Conclusions.—

Some lesions previously thought to be reactive are locally aggressive and demonstrate reproducible molecular abnormalities, and thus may be neoplasms. Although most common in the bones of the fingers and toes, these lesions also occur in long and other bones. The clinical presentations, radiologic appearances, and histopathologic features often overlap, making the diagnosis challenging, and these lesions may require molecular evaluation to maximize accurate prognostication.

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Author notes

Supported in part by the Haley's Hope Memorial Support Fund to GPS.

The authors have no relevant financial interest in the products or companies described in this article.

Presented in part at the Seventh Princeton Integrated Pathology Symposium; May 16, 2020; Plainsboro, New Jersey.