Sinonasal tract malignancies are rare cancers with frequent morphologic overlap. Given the similar histologic profiles seen in many of these entities, they often present a diagnostic challenge to the practicing pathologist.


To provide a streamlined algorithm using histologic clues, immunohistochemical profiles, and molecular assays to aid in diagnosis of these lesions.

Data Sources.—

Sources were the World Health Organization Tumor Classification, literature review, and institutional experience.


Although many sinonasal tract malignancies show similar histology, distinct immunohistochemical and molecular profiles can help parse out differences, thereby facilitating diagnosis for the pathologist.

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Author notes

The authors have no relevant financial interest in the products or companies described in this article.

Presented in part at the virtual Ninth Princeton Integrated Pathology Symposium; May 7, 2022.