Phosphate compounds in the red blood cells of vertebrates play an important role in modulating haemoglobin function whereby tissue oxygenation is maintained despite changes in both environmental oxygen supply and metabolic demand. Three examples from Gordon Grigg's work on aquatic ectotherms illustrate how our thinking has developed in terms of adaptive responses to seasonal temperature changes, environmental hypoxia, and ontogeny.
Allosteric modulation of haemoglobin function in response to changes in oxygen supply and demand: insights from aquatic ectotherms
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Rufus Wells; Allosteric modulation of haemoglobin function in response to changes in oxygen supply and demand: insights from aquatic ectotherms. Australian Zoologist 1 January 2010; 35 (2): 229–234. doi: https://doi.org/10.7882/AZ.2010.011
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