AAvian influenza H9N2 viruses circulate in all types of poultry species including turkeys and cause significant losses for the poultry industry in many parts of the word. The aim of this study was to assess the pathogenesis of the Moroccan avian influenza virus (AIV) H9N2 under experimental conditions in turkeys, and the protection efficacy of an inactivated commercial vaccine against AIV H9N2. Unvaccinated turkeys showed marked depression sinusitis, respiratory distress characterized by bronchiolar and tracheal rales of moderate severity and a mortality rate of 50%. Post mortem examinations of dead and euthanatized birds revealed the presence of fibrinous tracheitis, and airsacculitis lesions. Vaccination reduced the mortality rate to 30%. Vaccinated birds recovered at day 10 post challenge quickly and only 12.5% (1/8) and 37.5% of them still displayed fibrinous and non-fibrinous airsacculitis lesions respectively at day 15 post-inoculation. Viral shedding in cloacal and tracheal swabs was lower in vaccinated than in control birds. While viral RNA was detected in the cloacal swabs of all unvaccinated turkeys at day 3 post-inoculation, only 50% of the vaccinated turkeys were positive for virus detection. At day 11 post-inoculation, no viral RNA was detected in oropharyngeal swabs of vaccinated turkeys, while 40% of the unvaccinated turkeys were still shedding virus.
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Research Article|
August 26 2020
Pathogenicity of avian influenza virus subtype H9N2 in Turkeys and protection efficacy evaluation under experimental condition of an inactivated H9N2 vaccinePathogenesis of avian influenza virus subtype H9N2 in turkeys and evaluation of inactivated vaccine efficacy
Siham FELLAHI;
Siham FELLAHI
Institut Agronomique et Veterinaire Hassan II Head of avian pathology unit pathologie et santé publique vétérinaire BP 6202 , Rabat -Instituts, Morocco. MOROCCO Rabat 10000 00212660738577
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Saadia Nassik;
Saadia Nassik
Unité de Pathologie Aviaire, Département de Pathologie et Santé Publique Vétérinaire, Institut Agronomique et Vétérinaire Hassan II, Rabat, Morocco (10000)
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Imane Maaroufi;
Imane Maaroufi
Unité de Pathologie Aviaire, Département de Pathologie et Santé Publique Vétérinaire, Institut Agronomique et Vétérinaire Hassan II, Rabat, Morocco (10000)
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Nour-Said Tligui;
Nour-Said Tligui
Unité de Pathologie Aviaire, Département de Pathologie et Santé Publique Vétérinaire, Institut Agronomique et Vétérinaire Hassan II, Rabat, Morocco (10000)
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Charifa Drissi Touzani;
Charifa Drissi Touzani
Unité de Pathologie Aviaire, Département de Pathologie et Santé Publique Vétérinaire, Institut Agronomique et Vétérinaire Hassan II, Rabat, Morocco (10000)
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Taoufik Rawi;
Taoufik Rawi
MCI Santé Animale, Mohammedia, Maroc (23000)
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Mariette F. Ducatez;
Mariette F. Ducatez
INRAe UMR 1225 IHAP-ENVT, 31076 Toulouse, France
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Mohamed EL Houadfi
Mohamed EL Houadfi
Unité de Pathologie Aviaire, Département de Pathologie et Santé Publique Vétérinaire, Institut Agronomique et Vétérinaire Hassan II, Rabat, Morocco (10000)
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Avian Dis (2020)
Article history
Received:
June 11 2020
Revision Received:
August 20 2020
Accepted:
August 21 2020
Citation
Siham FELLAHI, Saadia Nassik, Imane Maaroufi, Nour-Said Tligui, Charifa Drissi Touzani, Taoufik Rawi, Mariette F. Ducatez, Mohamed EL Houadfi; Pathogenicity of avian influenza virus subtype H9N2 in Turkeys and protection efficacy evaluation under experimental condition of an inactivated H9N2 vaccinePathogenesis of avian influenza virus subtype H9N2 in turkeys and evaluation of inactivated vaccine efficacy. Avian Dis 2020; doi: https://doi.org/10.1637/aviandiseases-D-20-00067
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