We describe two new species of Proctoporus and a new species of Euspondylus (all from central Peru, Departamento de Huánuco, 2545 to 3010 m elevation). The new species are distinguished from all species presently assigned to Proctoporus and Euspondylus by unique characteristics of pholidosis, morphometrics, and color pattern. A key to the Peruvian species of Proctoporus and Euspondylus is provided. The current allocation of species to Proctoporus and Euspondylus may not reflect the phylogenetic relationships of the species under consideration. Based on the available data there appears to be no evidence to justify the separation of these genera. However, because of nomenclatural problems that would arise from synonymizing the two genera (e.g., producing a secondary homonymy in the case of Proctoporus guentheri Boettger and Ecpleopus guentheri O'Shaughnessy), we chose to retain the two genera until phylogenetic information is available.