A new species of Oreophrynella is described from Mount Ayanganna, a 2000 m plateau in the Pakaraima Mountains in west-central Guyana. The new species can be distinguished from other species of Oreophrynella by large size (snout–vent length up to 37.3 mm in females; 26.7 mm in males) absence of frontoparietal crests, orange-colored dorsum, and creamy yellow venter.

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