Background: Computerized cognitive training remains an attractive supplemental modality to enhance rehabilitation in multiple sclerosis (MS). The objective of the present study was to assess the usability of 3-dimensional multiple object tracking (3DMOT) in patients with MS.

Methods: In this pilot study, 16 patients with relapse-remitting MS and 9 healthy age-matched controls participated in four 30-minute training sessions of 3DMOT. Computerized neuropsychological tests, including driving readiness (i.e., UFOV) and cognitive function (i.e., Stroop, PVSAT, SDMT) were conducted at baseline and upon the conclusion of the training.

Results: While scoring lower on 3DMOT, patients with MS improved their 3DMOT scores in similar magnitude compared to healthy controls. 3DMOT training led to significant improvements in driving readiness in patients with MS. Taken together, 3DMOT training showed similar effectiveness in patients with MS compared to healthy, age-matched controls.

Conclusions: Training with 3DMOT may be an accessible and remotely administrable supplement to cognitive rehabilitation protocols for patients with MS.

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