Individuals with advanced multiple sclerosis (MS) have complex care requirements and are more likely to use long-term facilities. This study determined the associations between mood and social-care–related quality of life (SCRQOL), and healthrelated quality of life (HRQOL) and examined the association between HRQOL and SCRQOL.


Baseline data from a cohort study were used. Patients completed questionnaires, including the Hospital Anxiety and Depression Scale (HADS), Adult Social Care Outcomes Toolkit (ASCOT), and EuroQOL 5D-5L (EQ-5D-5L) and EQ-Visual Analogue Scale (EQVAS). Linear regression analyses were employed to assess the relationships between mood and both outcomes of QOL while controlling for relevant confounding factors (βs; 95% CI). The cross-sectional association between SCRQOL and HRQOL was examined using Pearson correlation coefficients (r).


A total of 75 patients, with a mean age of 56.1 years and a disease duration of 17.3 years, were enrolled from a long-term care facility in The Netherlands. Results showed that after controlling for confounders, HADS is an independent determinant of ASCOT (βs = – .368; 95% CI –.581 - –.154) and EQ-5D-5L (βs = -.297; 95% CI –.507 - –.087). Also, there are significant but weak correlations between ASCOT and EQ-5D-5L (r = .242; 95% CI, .015 - .468), between ASCOT and EQ-VAS (r = .230; 95% CI, .003 - .457) and between EQ-5D-5L and EQ-VAS (r = .227; 95% CI, .000 - .454).


Mood, especially the depression component, is an important determinant of both HRQOL and SCRQOL in advanced MS. Focusing on mood in health care and social care may contribute to the improvement of QOL in a broader sense.

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