This study measured quality of life (QOL) for transition-age youth with intellectual and developmental disabilities (IDD) and college youth without IDD. Transition-age youth with IDD (n = 19) and college youth without IDD (n = 30) were interviewed using the Quality of Life-Questionnaire (QOL-Q). One-way between-subjects analysis of variances (ANOVAs) and multivariable linear regression were used to explore differences between the groups and identify QOL predictors. Youth with IDD scored significantly lower on the QOL-Q than college youth without IDD. They scored lower in Independence, Community Integration, and Productivity; however, no significant difference was found in Satisfaction. Although studies have examined QOL for children, youth with autism spectrum disorder, and adults, additional research is needed on the factors that contribute to QOL among transition-age youth with IDD in order to improve the quality of their transition to adulthood.