Hemorrhagic cholecystitis is a rare cause of abdominal pain that presents in traumatic settings, malignancy, and bleeding diathesis. Herein, we report a case of hemorrhagic cholecystitis during anticoagulant therapy in a patient with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) who underwent a laparoscopic cholecystectomy. A 61-year-old female presented with abdominal pain and melena during hospitalization for SLE. She had a history of SLE and APS before this episode. She was diagnosed with hemorrhagic cholecystitis by ultrasonography (US), computed tomography (CT), and duodenoscopy. CT revealed a distended gallbladder containing a hy¬podense material suggestive of blood. The duodenoscopy revealed blood-mixed bile appearing from the papilla. Following conservative treatment, hemostasis was confirmed, and an elective laparoscopic cholecystectomy was performed based on the diagnosis of hemorrhagic cholecystitis. The open¬ing of the gallbladder revealed a large blood clot that gushed out, and multiple gallstones were also observed. The postoperative course was uneventful, and the patient has remained healthy without any complications.