Objective: To investigate which is the best surgical treatment for the gallbladder cancer patient. Summary Background Data: Up to now, the aggressive surgery for advanced gallbladder cancer is controversial. In this study, we analyzed gallbladder cancer patients' data retrospectively and want to find out which is the best surgical treatment for the patient. Methods: From 2009 to 2013, 315 cases of gallbladder carcinoma were identified. Data were analyzed retrospectively. The review included analysis of survival rate, postoperative complications, operative mortality rate, and correlation between local extent of the primary tumor and frequency of nodal metastases. Results: Postoperative complications occurred in 15 (6.2%) patients. 3% of patients who underwent a radical surgery procedure had complications, but in extended radical surgery group, it was 9.8%. Operative mortality rate is 4.94%. No lymph node metastases were found in patients with T1 tumors. Nodal involvement in patients with T3 (55.22%) and T4 (82.50%) tumors was significantly higher than that in patients with T2 (44.12%) tumors. In stage I and II patients, radical resection group had a better survival rate than simple cholecystectomy. In stage III patients, extend radical surgery group and radical surgery group showed a better survival rates than others. In stage IV patients, extend radical surgery group showed 4% survival rate at 2 year, but other group was 0. Conclusions: Simple cholecystectomy may decrease the long survival rates in stage I and II patients. In more advanced stages, extended radical resection should be performed if the R0 resections could be achieved.

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