Purpose: The placement of an internal stent through a pancreatic anastomosis is one of the surgical techniques to reduce the incidence of pancreatic fistula. However, the fate of the internal stent after placement remains unclear. The aim of this study was to evaluate stent-related complications and risk factors of stent migration through pancreaticojejunostomy in pancreaticoduodenectomy. Methods: We retrospectively analyzed 159 patients who underwent pancreaticoduodenectomy or subtotal stomach-preserving pancreaticoduodenectomy. Stent migration and stent defecation were confirmed by computed tomography. Risk factors of delayed detachment and migration of the stent were analyzed. Results: The median stent defecation time was 5.6 months and the stent was not expelled after 1 year in 33 patients (20.7%). Stent migration was detected in 11 patients (6.9%); the destination was always the hepatic duct. Stent-related complications were observed in 2 cases (1.3%). There were no significant risk factors of delayed detachment of the stent. Stent length Ã¢Â?Â¤25 mm was the only significant predictive risk factor of stent migration into the hepatic duct in multivariate analysis. Conclusion: The low rate of stent-related complications and the absence of serious adverse effects observed in this study justifies that the placement of the internal stent during pancreaticoduodenectomy. Cases with delayed defecation require close and long-term follow-up, especially if a short stent was used.