Malignant peritoneal mesothelioma is a rare disease with no established therapeutic method. A 79-year-old man underwent partial resection of the small intestine and right hemicolectomy for a bowel obstruction due to a mass in the small intestine and a submucosal tumour in the transverse colon. Malignant peritoneal mesothelioma was diagnosed from the excised specimen. After surgery, the patient received the cisplatin and pemetrexed therapy that is the standard treatment for malignant pleural mesothelioma. The progression of the remaining disseminated lesions could be controlled for a year, and the patient could lead a satisfactory life without adverse events. He had a bowel obstruction 12 months after the surgery, and showed increased fluorodeoxyglucose uptake and new sites of high fluorodeoxyglucose uptake. Positron emission tomography-computed tomography was useful as the index of disease progression. Despite a second resection, the patient died 14 months after the first surgery.

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