Objective : To evaluate the significance of preoperative neutrophil-lymphocyte ratio (NLR) for the analysis of disease-free survival (DFS) and overall survival (OS) in patients with stage II colorectal cancer (CRC).Summary of Background Data: Previous reports have indicated the association of NLR with a poor prognosis and tumor progression in patients with CRC. However, the role of NLR as a prognostic marker specifically in patients with stage II CRC has not been well studied.Methods : A total of 124 colon cancer patients were included in the study. The OS and DFS of patients were compared using preoperative NLR. Univariate and multivariate analyses using the Cox proportional hazards model were performed to determine the prognostic value of NLR.Results : The OS and DFS of patients with an NLR ≥ 4.0 were significantly lower when compared with those of patients with an NLR< 4.0. Multivariate analysis showed that NLR ≥ 4.0, PS score ≥ 1, and depth of tumor invasion T4 were independent prognostic factors for DFS, whereas age above 80 years, NLR ≥ 4.0, and PS score ≥ 1 were independent prognostic factors for OS.Conclusions : NLR can be considered a poor prognostic factor in patients with stage II CRC after curative surgery.
Significance of neutrophil-lymphocyte ratio (NLR) as a prognostic factor in Stage II colorectal cancer
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Masano Sagawa, HAJIME YOKOMIZO, KAZUHIKO YOSHIMATSU, SACHIYO OKAYAMA, YASUHUMI YAMADA, ARIKA IDA, HIROYUKI MAEDA, MASAYA SATAKE, TAKEBUMI USUI, TAKESHI SHIMAKAWA, TAKAO KATSUBE, SEIJI OHIGASHI, HIROYUKI KATO, SHUNICHI SHIOZAWA; Significance of neutrophil-lymphocyte ratio (NLR) as a prognostic factor in Stage II colorectal cancer. Int Surg 2020; doi: https://doi.org/10.9738/INTSURG-D-20-00025.1
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