Objective: The aim of this study was to clarify the predictive factors of recurrence-free time more than 10 years after primary hepatic resection for hepatocellular carcinoma (HCC).Summary of Background data: Surgical resection is a curative treatment for HCC patients with hepatic functional reserve; however, the high recurrence rate must be addressed.Methods: The study included 595 patients who had undergone curative resection for HCC. Multivariate analysis was performed to identify factors associated with recurrence-free survival more than 10 years.Results: Multivariate analysis revealed that tumor size ≤2 cm ( P = 0.004), ALBI grade 1 ( P = 0.03), FIB-4 index ≤3.3 ( P = 0.002), and histological inflammation grade ≤1 ( P = 0.03) were independent predictive factors for recurrence-free survival for more than 10 years. Predictive points were scored as follows: 2 points, tumor size ≤2 cm or FIB-4 index ≤3.3, and 1 point, ALBI grade 1 or histological inflammation grade ≤1. Patients were divided into three groups according to their total points: Group 1, 0–2 points (n = 317); Group 2, 3–4 points (n = 239); and Group 3, 5–6 points (n = 39). Recurrence-free survival rates among the three groups were significantly different ( P <0.0001). Conclusions: Tumor size, ALBI, FIB-4 index, and histological inflammation grade were independent predictive factors for recurrence-free survival longer than 10 years after curative hepatic resection for HCC.
Clinicopathological features of patients with primary hepatocellular carcinoma surviving without recurrence more than 10 years after primary hepatic resection
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Yusuke Yonemura, Tomoharu Yoshizumi, Takahiro Tomiyama, Norifumi Iseda, Akinari Morinaga, Kyohei Yugawa, Noboru Harada, Kazuki Takeishi, Takeo Toshima, Yoshihiro Nagao, Mohamed Eleman Elshawy, Mizuki Ninomiya, Tomohiro Iguchi, Shinji Itoh, Koshi Mimori, Masaki Mori; Clinicopathological features of patients with primary hepatocellular carcinoma surviving without recurrence more than 10 years after primary hepatic resection. Int Surg doi: https://doi.org/10.9738/INTSURG-D-20-00034.1
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