Statistical analysis provides an efficient alternative to the traditional Monte Carlo simulation for extremely low BER calculation in high speed serial link designs. Transmitter (TX) jitter posts a huge challenge in statistical simulation due to its pattern- and time-dependent nature and the resulting computational complexity. This paper presents a fast yet rigorous approach to calculate TX jitter in statistical simulation based on physical models of various jitter components. The approach accurately captures effects of uncorrelated random jitters, jitter amplification by channel dispersion, frequency dependency of periodic jitter and data duty-cycle-distortion.

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