Nephrotic syndrome in a seven-year-old Chinese shar pei resulted in oliguric renal failure, coagulopathy, and acute anemia. Renal amyloidosis and widespread thromboses were diagnosed postmortem. Splenic vein thrombosis caused significant splenic congestion, coagulative necrosis, and acute anemia. Splenic vein thrombosis is reported here as an unusual consequence of nephrotic syndrome in the dog.

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