A nine-year-old, castrated male golden retriever had lethargy, fever, massive peripheral lymphadenomegaly, hepatosplenomegaly, and pale mucous membranes. There was a marked leukocytosis (456.3 x 10(3) cells/microliter) with 99% blasts; a moderate, nonregenerative anemia; and marked thrombocytopenia. A tentative diagnosis of acute lymphocytic leukemia was made pending results of cytochemical staining. Despite the severity of the laboratory and clinical findings, the dog exhibited a partial response to an induction chemotherapy protocol commonly used for lymphoma. Subsequent cytochemical staining of the original blood and bone-marrow samples resulted in a revised diagnosis of acute myelomonocytic leukemia (AML-M4). Clinicopathological findings, response to treatment, and clinical outcome in this case of canine AML-M4 are discussed.
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1 January 1997
Articles|
January 01 1997
A potentially misleading presentation and course of acute myelomonocytic leukemia in a dog
J Am Anim Hosp Assoc (1997) 33 (1): 37–41.
Citation
TK Graves, CL Swenson, MA Scott; A potentially misleading presentation and course of acute myelomonocytic leukemia in a dog. J Am Anim Hosp Assoc 1 January 1997; 33 (1): 37–41. doi: https://doi.org/10.5326/15473317-33-1-37
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