Clinically ill feline leukemia virus (FeLV)-infected cats, treated with Staphylococcus protein A (SPA) or oral interferon alpha (IFN), or both, were compared with cats treated with saline (SAL). Nine cats received SPA/SAL, nine received SPA/IFN, 10 received SAL/IFN, and eight received SAL/SAL. Twelve cats survived and completed the 100-week therapy. Significantly more owners of cats treated with SPA/SAL thought their cat's health improved during treatment compared to owners of cats treated with SAL/SAL (P=0.05, pair-wise comparison) or SPA/IFN (P=0.05, pair-wise comparison). No significant differences in body weight, temperature, hematocrit, red blood cell counts, mean corpuscular hemoglobin concentration, reticulocyte counts, white blood cell or neutrophil numbers, lymphocyte concentrations, bone-marrow cytopathology, FeLV status, survival time, activity, or appetite scores were observed. No significant differences in the owners' subjective assessment of their cat's health following treatment with SAL/IFN, SPA/IFN, or SAL/SAL were seen. Therapy with SPA as a single agent results in the owners' subjective impression of improved health of their FeLV-infected cats.
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July/August 2001
Articles|
July 01 2001
Immunomodulation therapy for feline leukemia virus infection
J Am Anim Hosp Assoc (2001) 37 (4): 356–363.
Citation
DL McCaw, GD Boon, AE Jergens, MR Kern, MH Bowles, JC Johnson; Immunomodulation therapy for feline leukemia virus infection. J Am Anim Hosp Assoc 1 July 2001; 37 (4): 356–363. doi: https://doi.org/10.5326/15473317-37-4-356
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