Eighteen dogs with monoclonal gammopathies were evaluated retrospectively. Most of the cases were associated with lymphoproliferative tumors (i.e., nine multiple myelomas, one Waldenström’s macroglobulinemia, one lymphoma, one chronic lymphocytic leukemia, and one mucocutaneous plasmacytoma). The prevalence of nonmyelomatous monoclonal gammopathies (28%) was also significant (three leishmaniasis and two ehrlichiosis). Presenting complaints and clinical signs often were nonspecific or related to bleeding diathesis. Significant laboratory findings included proteinuria, hypoalbuminemia, and anemia. Some unusual features were also observed: a multiple myeloma with immunoglobulin M secretion, another myeloma with two narrow spikes on the electrophoretic pattern, and a mucocutaneous plasmacytoma secreting an immunoglobulin G paraprotein.
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March/April 2002
Internal Medicine|
March 01 2002
Monoclonal Gammopathies in the Dog: A Retrospective Study of 18 Cases (1986–1999) and Literature Review
Jérôme M. Giraudel, DVM;
Jérôme M. Giraudel, DVM
Department of Small Animal Clinical Sciences (Giraudel, Guelfi), National Veterinary School of Toulouse, 23 chemin des Capelles, 31076 Toulouse Cedex 3, France and the
Croix du Sud Veterinary Clinical Practice (Pagès), 45 avenue de Toulouse, 31650 Saint-Orens de Gameville, France
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Jean-Pierre Pagès, DVM, Diplomate ECVIM;
Jean-Pierre Pagès, DVM, Diplomate ECVIM
Department of Small Animal Clinical Sciences (Giraudel, Guelfi), National Veterinary School of Toulouse, 23 chemin des Capelles, 31076 Toulouse Cedex 3, France and the
Croix du Sud Veterinary Clinical Practice (Pagès), 45 avenue de Toulouse, 31650 Saint-Orens de Gameville, France
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Jean-François Guelfi, DVM
Jean-François Guelfi, DVM
Department of Small Animal Clinical Sciences (Giraudel, Guelfi), National Veterinary School of Toulouse, 23 chemin des Capelles, 31076 Toulouse Cedex 3, France and the
Croix du Sud Veterinary Clinical Practice (Pagès), 45 avenue de Toulouse, 31650 Saint-Orens de Gameville, France
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J Am Anim Hosp Assoc (2002) 38 (2): 135–147.
Citation
Jérôme M. Giraudel, Jean-Pierre Pagès, Jean-François Guelfi; Monoclonal Gammopathies in the Dog: A Retrospective Study of 18 Cases (1986–1999) and Literature Review. J Am Anim Hosp Assoc 1 March 2002; 38 (2): 135–147. doi: https://doi.org/10.5326/0380135
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