Sex-linked muscular dystrophy associated with dystrophin deficiency has been reported in several breeds of dogs and is best characterized in the golden retriever. In this case report, a young, male Labrador retriever with dystrophin-deficient muscular dystrophy is presented. Clinical signs included generalized weakness, lingual hypertrophy, and dysphagia. Electromyographic abnormalities including complex repetitive discharges were present. Serum creatine kinase concentration was dramatically elevated. Histopathological changes within a muscle biopsy specimen confirmed a dystrophic myopathy, and dystrophin deficiency was demonstrated by immunohisto-chemical staining. While X-linked muscular dystrophy has not previously been reported in the Labrador retriever, a hereditary myopathy with an autosomal recessive mode of inheritance has been characterized. A correct diagnosis and classification of these two disorders are critical for breeders and owners since both the mode of inheritance and the prognosis differ.
Skip Nav Destination
Article navigation
May/June 2002
other|
May 01 2002
Dystrophin-Deficient Muscular Dystrophy in a Labrador Retriever
Robert L. Bergman, DVM;
Robert L. Bergman, DVM
Department of Small Animal Clinical Sciences (Bergman, Inzana, Monroe, Shell), Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia 24061; the
Burnham Institute (Liu, Engvall), La Jolla, California 92037; and the
Department of Pathology (Shelton), University of California–San Diego, La Jolla, California 92093
From the
Search for other works by this author on:
Karen D. Inzana, DVM, PhD, Diplomate ACVIM;
Karen D. Inzana, DVM, PhD, Diplomate ACVIM
Department of Small Animal Clinical Sciences (Bergman, Inzana, Monroe, Shell), Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia 24061; the
Burnham Institute (Liu, Engvall), La Jolla, California 92037; and the
Department of Pathology (Shelton), University of California–San Diego, La Jolla, California 92093
From the
Search for other works by this author on:
William E. Monroe, DVM, MS, Diplomate ACVIM;
William E. Monroe, DVM, MS, Diplomate ACVIM
Department of Small Animal Clinical Sciences (Bergman, Inzana, Monroe, Shell), Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia 24061; the
Burnham Institute (Liu, Engvall), La Jolla, California 92037; and the
Department of Pathology (Shelton), University of California–San Diego, La Jolla, California 92093
From the
Search for other works by this author on:
Linda G. Shell, DVM, Diplomate ACVIM;
Linda G. Shell, DVM, Diplomate ACVIM
Department of Small Animal Clinical Sciences (Bergman, Inzana, Monroe, Shell), Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia 24061; the
Burnham Institute (Liu, Engvall), La Jolla, California 92037; and the
Department of Pathology (Shelton), University of California–San Diego, La Jolla, California 92093
From the
Search for other works by this author on:
Ling A. Liu, PhD;
Ling A. Liu, PhD
Department of Small Animal Clinical Sciences (Bergman, Inzana, Monroe, Shell), Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia 24061; the
Burnham Institute (Liu, Engvall), La Jolla, California 92037; and the
Department of Pathology (Shelton), University of California–San Diego, La Jolla, California 92093
From the
Search for other works by this author on:
Eva Engvall, PhD;
Eva Engvall, PhD
Department of Small Animal Clinical Sciences (Bergman, Inzana, Monroe, Shell), Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia 24061; the
Burnham Institute (Liu, Engvall), La Jolla, California 92037; and the
Department of Pathology (Shelton), University of California–San Diego, La Jolla, California 92093
From the
Search for other works by this author on:
G. Diane Shelton, DVM, PhD, Diplomate ACVIM
G. Diane Shelton, DVM, PhD, Diplomate ACVIM
Department of Small Animal Clinical Sciences (Bergman, Inzana, Monroe, Shell), Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia 24061; the
Burnham Institute (Liu, Engvall), La Jolla, California 92037; and the
Department of Pathology (Shelton), University of California–San Diego, La Jolla, California 92093
From the
Search for other works by this author on:
J Am Anim Hosp Assoc (2002) 38 (3): 255–261.
Citation
Robert L. Bergman, Karen D. Inzana, William E. Monroe, Linda G. Shell, Ling A. Liu, Eva Engvall, G. Diane Shelton; Dystrophin-Deficient Muscular Dystrophy in a Labrador Retriever. J Am Anim Hosp Assoc 1 May 2002; 38 (3): 255–261. doi: https://doi.org/10.5326/0380255
Download citation file:
Sign in
Don't already have an account? Register
Client Account
You could not be signed in. Please check your email address / username and password and try again.
Sign in via your Institution
Sign in via your InstitutionCiting articles via
Evaluation of Intrathecal Injection of Modified Live Newcastle Disease Virus Vaccine in Dogs with Canine Distemper Encephalitis
Kenneth R. Harkin, DVM, DACVIM, Anushka George Karote, MS
Assessment of Adrenal Computed Tomography Characteristics in Cats with Nonadrenal Disease
Stefanie Gaisbauer, DVM, Florian Karl Zeugswetter, Priv. Doz., DVM, Alexander Tichy, Mag. phil., Dr. rer. nat., Conor Rowan, MVB, DVMS, DECVDI, MRCVS, Eberhard Ludewig, DMV habil., DECVDI
Prolonged Survival Following Treatment of Histiocytic Sarcoma of the Canine Urinary Bladder
Steve Patten, DVM, MSc, DACVIM (Oncology), Shawn MacKenzie, DVM, DVSc, DACVR
Anicteric Gallbladder Rupture with Elevated Bile Acids in Abdominal Effusion in a Dog with Cholecystitis
Mireia Pascual, DVM, Emilie Fauchon, DECVDI, Paola Monti, DACVP, Ferran Valls, DECVIM
Cholesterol Granuloma of the Cranial Mediastinum in a Dog
Anastacia Marie Davis, DVM, MS, DACVS, Kevin Lahmers, DVM, PhD, DACVP, Brie Trusiano, DVM, Kurt Zimmerman, DVM, PhD, DACVP, Jake Romeiser, DVM, Joanne Tuohy, DVM, PhD