Pertinent patient data and biopsied tissue from 16 cases of canine synovial sarcoma (SS) were reviewed. Histopathological grade, clinical stage, and tissue immunoreactivity to cytokeratin (broad stain, AE1/AE3 and cytokeratin 7) and vimentin were determined and correlated with survival. Effect of treatment on survival was similarly evaluated. Neither clinical stage nor histopathological grade significantly affected survival patterns. Tissues from all cases stained >30% positively with vimentin, whereas no tissue from any case exhibited cytokeratin immunoreactivity. Dogs receiving surgical tumor excision or amputation had a significantly higher survivability than those receiving no treatment (P<0.02). Treatment aggressiveness may be more appropriate than clinical staging or tumor grading in predicting survival. Reliability of diagnosing and prognosticating canine SS with current immunohistochemistry protocols should be questioned.
Skip Nav Destination
Article navigation
July/August 2002
Oncology|
July 01 2002
Canine Synovial Sarcoma: A Retrospective Assessment of Described Prognostic Criteria in 16 Cases (1994–1999)
Derek B. Fox, DVM;
Derek B. Fox, DVM
Comparative Orthopaedic Laboratory (Fox, Cook, Kreeger), the Veterinary Medical Diagnostic Laboratory of the Department of Pathobiology (Beissenherz), and the
Department of Veterinary Medicine and Surgery (Henry), College of Veterinary Medicine, University of Missouri-Columbia, 379 East Campus Drive, Columbia, Missouri 65211
From the
Search for other works by this author on:
James L. Cook, DVM, PhD, Diplomate ACVS;
James L. Cook, DVM, PhD, Diplomate ACVS
Comparative Orthopaedic Laboratory (Fox, Cook, Kreeger), the Veterinary Medical Diagnostic Laboratory of the Department of Pathobiology (Beissenherz), and the
Department of Veterinary Medicine and Surgery (Henry), College of Veterinary Medicine, University of Missouri-Columbia, 379 East Campus Drive, Columbia, Missouri 65211
From the
Search for other works by this author on:
John M. Kreeger, DVM, PhD, Diplomate ACVP;
John M. Kreeger, DVM, PhD, Diplomate ACVP
Comparative Orthopaedic Laboratory (Fox, Cook, Kreeger), the Veterinary Medical Diagnostic Laboratory of the Department of Pathobiology (Beissenherz), and the
Department of Veterinary Medicine and Surgery (Henry), College of Veterinary Medicine, University of Missouri-Columbia, 379 East Campus Drive, Columbia, Missouri 65211
From the
Search for other works by this author on:
Marilyn Beissenherz, BS, HT (ASCP);
Marilyn Beissenherz, BS, HT (ASCP)
Comparative Orthopaedic Laboratory (Fox, Cook, Kreeger), the Veterinary Medical Diagnostic Laboratory of the Department of Pathobiology (Beissenherz), and the
Department of Veterinary Medicine and Surgery (Henry), College of Veterinary Medicine, University of Missouri-Columbia, 379 East Campus Drive, Columbia, Missouri 65211
From the
Search for other works by this author on:
Carolyn J. Henry, DVM, MS, Diplomate ACVIM (Oncology)
Carolyn J. Henry, DVM, MS, Diplomate ACVIM (Oncology)
Comparative Orthopaedic Laboratory (Fox, Cook, Kreeger), the Veterinary Medical Diagnostic Laboratory of the Department of Pathobiology (Beissenherz), and the
Department of Veterinary Medicine and Surgery (Henry), College of Veterinary Medicine, University of Missouri-Columbia, 379 East Campus Drive, Columbia, Missouri 65211
From the
Search for other works by this author on:
J Am Anim Hosp Assoc (2002) 38 (4): 347–355.
Citation
Derek B. Fox, James L. Cook, John M. Kreeger, Marilyn Beissenherz, Carolyn J. Henry; Canine Synovial Sarcoma: A Retrospective Assessment of Described Prognostic Criteria in 16 Cases (1994–1999). J Am Anim Hosp Assoc 1 July 2002; 38 (4): 347–355. doi: https://doi.org/10.5326/0380347
Download citation file:
Sign in
Don't already have an account? Register
Client Account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Sign in via your Institution
Sign in via your InstitutionCiting articles via
Long-Term Survival of Primary Intracranial Histiocytic Sarcoma Through Surgical Resection and Low-Dose CCNU
Kyosuke Hidari, DVM, Yuya Nakamoto, DVM, PhD, James K. Chambers, DVM, PhD, Kazuyuki Uchida, DVM, PhD, Isao Mori, DVM, Miwa Nakamoto, DVM
Microfilaria in the Urine of a Dog with Concurrent Urinary Bladder Sarcoma
Nicole Schlette, DVM, Erin Burton, DVM, MS, DACVP, Amber Harris, DVM, DACVIM (Internal Medicine), Kendall Langsten, DVM, DACVP, Erik Olson, DVM, PhD, DACVP, Daniel Heinrich, DVM, DACVP
Chronic Myelomonocytic Leukemia with Central Nervous System Involvement in a Dog
Ilaria Tartari, DVM, Fabio Tocco, DVM, Giorgio Cancedda, DVM, Veronica Angioni, DVM, Marco Podda, DVM, Antonella Gallucci, DVM, PhD, DECVN, EBVS
Treatment Outcomes of Canine Orbital Meningiomas in Seven Cases
Akihiro Uno, DVM, Ryota Iwasaki, DVM, PhD, Takashi Mori, DVM, PhD
Transient Hypoadrenocorticism in a 7-Week-Old Kitten
Alba Planas Vintro, BVM, Linda G. Martin, DVM, MS, DACVECC, Cassidy L. Cordon, DVM, Sabrina N. Hoehne, Dr. med. vet., DACVECC, DECVECC, Elizabeth B. Davidow, DVM, DACVECC