A placebo-controlled experiment was performed to evaluate the effect of potassium bromide on the canine thyroid gland. Basal total thyroxine, free thyroxine, and basal thyrotropin serum concentrations were evaluated over a 6-month period in potassium bromide-treated and control dogs. A thyrotropin-releasing hormone stimulation test was also performed in all dogs at the beginning and conclusion of the study. Thyroid histopathology was compared between treated and control dogs at the end of the study. No difference was detected in any parameter between the two groups at the end of the study. A decline in thyroid hormone concentrations over the course of the study did occur in both groups of dogs. Potassium bromide does not appear to have a significant effect on canine thyroid function or morphology.
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March/April 2003
Internal Medicine|
March 01 2003
Effect of Anticonvulsant Dosages of Potassium Bromide on Thyroid Function and Morphology in Dogs
Lisa C. Paull, DVM;
Lisa C. Paull, DVM
Department of Clinical Sciences (Paull, Scott-Moncrieff, DeNicola), Center for the Human-Animal Bond (N. Glickman),
Department of Veterinary Pathobiology (L. Glickman), School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907-1248 and the
Endocrine Section (Refsal), Animal Health Diagnostic Laboratory, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824-1316
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J. Catharine R. Scott-Moncrieff, MA, VetMB, MS, MRCVS, Diplomate ACVIM, Diplomate ECVIM;
J. Catharine R. Scott-Moncrieff, MA, VetMB, MS, MRCVS, Diplomate ACVIM, Diplomate ECVIM
Department of Clinical Sciences (Paull, Scott-Moncrieff, DeNicola), Center for the Human-Animal Bond (N. Glickman),
Department of Veterinary Pathobiology (L. Glickman), School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907-1248 and the
Endocrine Section (Refsal), Animal Health Diagnostic Laboratory, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824-1316
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Dennis B. DeNicola, DVM, PhD, Diplomate ACVP;
Dennis B. DeNicola, DVM, PhD, Diplomate ACVP
Department of Clinical Sciences (Paull, Scott-Moncrieff, DeNicola), Center for the Human-Animal Bond (N. Glickman),
Department of Veterinary Pathobiology (L. Glickman), School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907-1248 and the
Endocrine Section (Refsal), Animal Health Diagnostic Laboratory, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824-1316
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Nita Glickman, MS, MPH;
Nita Glickman, MS, MPH
Department of Clinical Sciences (Paull, Scott-Moncrieff, DeNicola), Center for the Human-Animal Bond (N. Glickman),
Department of Veterinary Pathobiology (L. Glickman), School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907-1248 and the
Endocrine Section (Refsal), Animal Health Diagnostic Laboratory, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824-1316
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Kent R. Refsal, DVM, PhD;
Kent R. Refsal, DVM, PhD
Department of Clinical Sciences (Paull, Scott-Moncrieff, DeNicola), Center for the Human-Animal Bond (N. Glickman),
Department of Veterinary Pathobiology (L. Glickman), School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907-1248 and the
Endocrine Section (Refsal), Animal Health Diagnostic Laboratory, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824-1316
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Larry T. Glickman, VMD, DrPh, FACE
Larry T. Glickman, VMD, DrPh, FACE
Department of Clinical Sciences (Paull, Scott-Moncrieff, DeNicola), Center for the Human-Animal Bond (N. Glickman),
Department of Veterinary Pathobiology (L. Glickman), School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907-1248 and the
Endocrine Section (Refsal), Animal Health Diagnostic Laboratory, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824-1316
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J Am Anim Hosp Assoc (2003) 39 (2): 193–202.
Citation
Lisa C. Paull, J. Catharine R. Scott-Moncrieff, Dennis B. DeNicola, Nita Glickman, Kent R. Refsal, Larry T. Glickman; Effect of Anticonvulsant Dosages of Potassium Bromide on Thyroid Function and Morphology in Dogs. J Am Anim Hosp Assoc 1 March 2003; 39 (2): 193–202. doi: https://doi.org/10.5326/0390193
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