Immunoglobulin A is the predominant secretory antibody at mucosal surfaces. In the dog, immunoglobulin A deficiency (IgAD) is characterized by low to absent serum IgA and normal to elevated serum immunoglobulin G (IgG) and immunoglobulin M (IgM) concentrations. However, studies comparing serum and secretory IgA in dogs have often documented a poor correlation, suggesting that serum concentrations should not be used to estimate mucosal secretion of this antibody. This report demonstrates the concurrent use of serum IgA, IgG, and IgM; secretory IgA (from bronchoalveolar lavage fluid); and immunohistochemical stains on bronchial and duodenal mucosa for IgA-containing B cells in a young Irish setter with recurrent respiratory and gastrointestinal signs.
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May/June 2003
Internal Medicine|
May 01 2003
Evaluation of Systemic and Secretory IgA Concentrations and Immunohistochemical Stains for IgA-Containing B Cells in Mucosal Tissues of an Irish Setter With Selective IgA Deficiency
Carol R. Norris, DVM, Diplomate ACVIM;
Carol R. Norris, DVM, Diplomate ACVIM
Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, California 95616
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Laurel J. Gershwin, DVM, PhD
Laurel J. Gershwin, DVM, PhD
Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, California 95616
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J Am Anim Hosp Assoc (2003) 39 (3): 247–250.
Citation
Carol R. Norris, Laurel J. Gershwin; Evaluation of Systemic and Secretory IgA Concentrations and Immunohistochemical Stains for IgA-Containing B Cells in Mucosal Tissues of an Irish Setter With Selective IgA Deficiency. J Am Anim Hosp Assoc 1 May 2003; 39 (3): 247–250. doi: https://doi.org/10.5326/0390247
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