A hereditary basis for congenital portosystemic shunts (PSS) in Yorkshire terriers was explored through record and pedigree analysis and a breeding trial. The odds ratio for PSS in Yorkshire terriers was 35.9 times greater than for all other breeds combined. Wright’s coefficient of inbreeding was approximately twice as high for Yorkshire terriers with PSS as compared to normal members of the breed (P=0.09). No common ancestors were found that were significant to the PSS group. Two affected Yorkshire terriers were bred and produced two normal puppies. Congenital PSS appears to be hereditary in Yorkshire terriers; however, the mechanism of inheritance has yet to be elucidated.

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