Six dogs were entered into a 30-day, prospective, nonrandomized, uncontrolled clinical trial evaluating the effects of an oral preparation of budesonide on the hypothalamic-pituitary-adrenal (HPA) axis during therapeutic management of active inflammatory bowel disease. Oral budesonide, at a dose of 3 mg/m2, was administered once daily. Upon entry and completion of the trial, serum basal cortisol, adrenocorticotropic (ACTH)-stimulated cortisol, endogenous ACTH concentration, serum alkaline phosphatase (SAP) activity, and urine specific gravity were evaluated, as well as owner assessment of glucocorticoid-associated side effects. Significant suppression of the HPA axis occurred. No significant differences in SAP activity, urine specific gravity, or owner-subjective assessments were detected.
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March/April 2004
Internal Medicine|
March 01 2004
Clinical Effects of Short-Term Oral Budesonide on the Hypothalamic-Pituitary-Adrenal Axis in Dogs With Inflammatory Bowel Disease
Joshua W. Tumulty, DVM, Diplomate ACVIM;
Joshua W. Tumulty, DVM, Diplomate ACVIM
The Animal Medical Center (Tumulty, Broussard, Peterson), E & M Bobst Hospital, Caspary Research Institute, 510 East 62nd Street, New York, New York 10021-8314 and the Gastrointestinal Laboratory (Steiner, Williams), Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, College Station, Texas 77843-4474
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John D. Broussard, DVM, Diplomate ACVIM;
John D. Broussard, DVM, Diplomate ACVIM
The Animal Medical Center (Tumulty, Broussard, Peterson), E & M Bobst Hospital, Caspary Research Institute, 510 East 62nd Street, New York, New York 10021-8314 and the Gastrointestinal Laboratory (Steiner, Williams), Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, College Station, Texas 77843-4474
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Jörg M. Steiner, med.vet., Dr.med.vet., PhD, Diplomate ACVIM, Diplomate ECVIM-CA;
Jörg M. Steiner, med.vet., Dr.med.vet., PhD, Diplomate ACVIM, Diplomate ECVIM-CA
The Animal Medical Center (Tumulty, Broussard, Peterson), E & M Bobst Hospital, Caspary Research Institute, 510 East 62nd Street, New York, New York 10021-8314 and the Gastrointestinal Laboratory (Steiner, Williams), Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, College Station, Texas 77843-4474
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Mark E. Peterson, DVM, Diplomate ACVIM;
Mark E. Peterson, DVM, Diplomate ACVIM
The Animal Medical Center (Tumulty, Broussard, Peterson), E & M Bobst Hospital, Caspary Research Institute, 510 East 62nd Street, New York, New York 10021-8314 and the Gastrointestinal Laboratory (Steiner, Williams), Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, College Station, Texas 77843-4474
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David A. Williams, MA, Vet. MB, PhD, MRCVS, Diplomate ACVIM
David A. Williams, MA, Vet. MB, PhD, MRCVS, Diplomate ACVIM
The Animal Medical Center (Tumulty, Broussard, Peterson), E & M Bobst Hospital, Caspary Research Institute, 510 East 62nd Street, New York, New York 10021-8314 and the Gastrointestinal Laboratory (Steiner, Williams), Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, Texas A&M University, College Station, Texas 77843-4474
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J Am Anim Hosp Assoc (2004) 40 (2): 120–123.
Citation
Joshua W. Tumulty, John D. Broussard, Jörg M. Steiner, Mark E. Peterson, David A. Williams; Clinical Effects of Short-Term Oral Budesonide on the Hypothalamic-Pituitary-Adrenal Axis in Dogs With Inflammatory Bowel Disease. J Am Anim Hosp Assoc 1 March 2004; 40 (2): 120–123. doi: https://doi.org/10.5326/0400120
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