A 1.5-year-old Doberman pinscher was presented with sudden-onset of fever and malaise. Twelve days prior to presentation, fenbendazole therapy was initiated for a suspected lungworm infection. Results of a complete blood count on presentation showed pancytopenia, while histopathological evaluation of a bone marrow core sample revealed bone marrow hypoplasia of undetermined etiology. Bactericidal antibiotics and fluid therapy, as well as discontinuation of fenbendazole administration, led to a complete resolution of clinical and hematological abnormalities within 15 days. An idiosyncratic reaction to fenbendazole was suspected based on the absence of infectious, neoplastic, autoimmune, and toxic etiologies, as well as resolution of clinical signs and pancytopenia upon drug withdrawal.
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May/June 2004
Case Reports|
May 01 2004
Bone Marrow Hypoplasia Associated With Fenbendazole Administration in a Dog
Anthony T. Gary, DVM;
Anthony T. Gary, DVM
Department of Veterinary Medicine and Surgery (Gary, Kerl, Cohn) and the Veterinary Medical Diagnostic Laboratory (Wiedmeyer, Turnquist), College of Veterinary Medicine, University of Missouri-Columbia, Columbia, Missouri 65211
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Marie E. Kerl, DVM, Diplomate ACVIM, Diplomate ACVECC;
Marie E. Kerl, DVM, Diplomate ACVIM, Diplomate ACVECC
Department of Veterinary Medicine and Surgery (Gary, Kerl, Cohn) and the Veterinary Medical Diagnostic Laboratory (Wiedmeyer, Turnquist), College of Veterinary Medicine, University of Missouri-Columbia, Columbia, Missouri 65211
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Charles E. Wiedmeyer, DVM, PhD;
Charles E. Wiedmeyer, DVM, PhD
Department of Veterinary Medicine and Surgery (Gary, Kerl, Cohn) and the Veterinary Medical Diagnostic Laboratory (Wiedmeyer, Turnquist), College of Veterinary Medicine, University of Missouri-Columbia, Columbia, Missouri 65211
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Susan E. Turnquist, DVM, PhD, Diplomate ACVP;
Susan E. Turnquist, DVM, PhD, Diplomate ACVP
Department of Veterinary Medicine and Surgery (Gary, Kerl, Cohn) and the Veterinary Medical Diagnostic Laboratory (Wiedmeyer, Turnquist), College of Veterinary Medicine, University of Missouri-Columbia, Columbia, Missouri 65211
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Leah A. Cohn, DVM, PhD, Diplomate ACVIM
Leah A. Cohn, DVM, PhD, Diplomate ACVIM
Department of Veterinary Medicine and Surgery (Gary, Kerl, Cohn) and the Veterinary Medical Diagnostic Laboratory (Wiedmeyer, Turnquist), College of Veterinary Medicine, University of Missouri-Columbia, Columbia, Missouri 65211
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J Am Anim Hosp Assoc (2004) 40 (3): 224–229.
Citation
Anthony T. Gary, Marie E. Kerl, Charles E. Wiedmeyer, Susan E. Turnquist, Leah A. Cohn; Bone Marrow Hypoplasia Associated With Fenbendazole Administration in a Dog. J Am Anim Hosp Assoc 1 May 2004; 40 (3): 224–229. doi: https://doi.org/10.5326/0400224
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