Serological tests were performed on 380 cats with necropsy-confirmed heartworm status to compare the performance of currently available commercial laboratory and point-of-care heart-worm serological tests in a heartworm-endemic area. Overall, antigen tests detected 79.3% to 86.2% of heartworm infections and were highly specific. Most cats with false-negative antigen tests had a single male worm. Antibody tests detected 62.1% to 72.4% of heartworm infections and had a wider range of false-positive results (1.4% to 19.1%) than antigen tests (0.3% to 2.0%). Serological tests for feline heartworm infection varied in diagnostic performance. Combining results from antigen and antibody tests achieved greater sensitivity than using either test alone.
Comparison of Serological Tests for the Detection of Natural Heartworm Infection in Cats
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Paul Berdoulay, Julie K. Levy, Patti S. Snyder, Michael J. Pegelow, Jennifer L. Hooks, Larissa M. Tavares, Nicole M. Gibson, Marc E. Salute; Comparison of Serological Tests for the Detection of Natural Heartworm Infection in Cats. J Am Anim Hosp Assoc 1 September 2004; 40 (5): 376–384. doi: https://doi.org/10.5326/0400376
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