A total of 100 Pseudomonas aeruginosa (P. aeruginosa) isolates were collected over a 1.5- year period from cases of canine otitis. Sensitivities to enrofloxacin, marbofloxacin, and orbifloxacin were determined using minimum inhibitory concentration testing (MICT). Isolates were also tested for sensitivities to enrofloxacin and marbofloxacin using disk-diffusion susceptibility testing (DDST). Isolates were significantly more sensitive to marbofloxacin than to enrofloxacin (z = −4.57; P<0.05) or orbifloxacin (z = −5.02; P<0.05). Agreement was 87% between MICT and DDST for marbofloxacin, with approximately equal numbers of overestimation and underestimation errors. Agreement was 74% between MICT and DDST for enrofloxacin, but DDST tended to overestimate the number of enrofloxacin-susceptible strains. These results suggest that marbofloxacin is more effective against P. aeruginosa than either enrofloxacin or orbifloxacin and that relying on DDST may lead to ineffective enrofloxacin treatment.
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November/December 2007
Dermatology|
November 01 2007
Antimicrobial Testing of Selected Fluoroquinolones Against Pseudomonas aeruginosa Isolated From Canine Otitis
Lindsay McKay, DVM, Diplomate ACVD;
Lindsay McKay, DVM, Diplomate ACVD
Department of Dermatology (McKay, Matousek), VCA-Aurora Animal Hospital, 2600 West Galena Boulevard, Aurora, Illinois 60506; the
Department of Infectious Disease and Pathology (Schuman Rose, Gaskin), College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610; the
Department of Dermatology (Schmeitzel), VCA-Berwyn Animal Hospital, 2845 South Harlem Avenue, Berwyn, Illinois 60305;
Valdosta State University (Gibson), 1500 North Patterson Street, Valdosta, Georgia 31698
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Crystal D. Schuman Rose, BS;
Crystal D. Schuman Rose, BS
Department of Dermatology (McKay, Matousek), VCA-Aurora Animal Hospital, 2600 West Galena Boulevard, Aurora, Illinois 60506; the
Department of Infectious Disease and Pathology (Schuman Rose, Gaskin), College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610; the
Department of Dermatology (Schmeitzel), VCA-Berwyn Animal Hospital, 2845 South Harlem Avenue, Berwyn, Illinois 60305;
Valdosta State University (Gibson), 1500 North Patterson Street, Valdosta, Georgia 31698
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Jennifer L. Matousek, DVM, MS, Diplomate ACVD;
Jennifer L. Matousek, DVM, MS, Diplomate ACVD
Department of Dermatology (McKay, Matousek), VCA-Aurora Animal Hospital, 2600 West Galena Boulevard, Aurora, Illinois 60506; the
Department of Infectious Disease and Pathology (Schuman Rose, Gaskin), College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610; the
Department of Dermatology (Schmeitzel), VCA-Berwyn Animal Hospital, 2845 South Harlem Avenue, Berwyn, Illinois 60305;
Valdosta State University (Gibson), 1500 North Patterson Street, Valdosta, Georgia 31698
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Lynn S. Schmeitzel, DVM, Diplomate ACVD;
Lynn S. Schmeitzel, DVM, Diplomate ACVD
Department of Dermatology (McKay, Matousek), VCA-Aurora Animal Hospital, 2600 West Galena Boulevard, Aurora, Illinois 60506; the
Department of Infectious Disease and Pathology (Schuman Rose, Gaskin), College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610; the
Department of Dermatology (Schmeitzel), VCA-Berwyn Animal Hospital, 2845 South Harlem Avenue, Berwyn, Illinois 60305;
Valdosta State University (Gibson), 1500 North Patterson Street, Valdosta, Georgia 31698
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Nicole M. Gibson, PhD;
Nicole M. Gibson, PhD
Department of Dermatology (McKay, Matousek), VCA-Aurora Animal Hospital, 2600 West Galena Boulevard, Aurora, Illinois 60506; the
Department of Infectious Disease and Pathology (Schuman Rose, Gaskin), College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610; the
Department of Dermatology (Schmeitzel), VCA-Berwyn Animal Hospital, 2845 South Harlem Avenue, Berwyn, Illinois 60305;
Valdosta State University (Gibson), 1500 North Patterson Street, Valdosta, Georgia 31698
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Jack M. Gaskin, DVM, PhD, Diplomate ACVM (Microbiology)
Jack M. Gaskin, DVM, PhD, Diplomate ACVM (Microbiology)
Department of Dermatology (McKay, Matousek), VCA-Aurora Animal Hospital, 2600 West Galena Boulevard, Aurora, Illinois 60506; the
Department of Infectious Disease and Pathology (Schuman Rose, Gaskin), College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610; the
Department of Dermatology (Schmeitzel), VCA-Berwyn Animal Hospital, 2845 South Harlem Avenue, Berwyn, Illinois 60305;
Valdosta State University (Gibson), 1500 North Patterson Street, Valdosta, Georgia 31698
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J Am Anim Hosp Assoc (2007) 43 (6): 307–312.
Citation
Lindsay McKay, Crystal D. Schuman Rose, Jennifer L. Matousek, Lynn S. Schmeitzel, Nicole M. Gibson, Jack M. Gaskin; Antimicrobial Testing of Selected Fluoroquinolones Against Pseudomonas aeruginosa Isolated From Canine Otitis. J Am Anim Hosp Assoc 1 November 2007; 43 (6): 307–312. doi: https://doi.org/10.5326/0430307
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