Pseudothrombocytopenia (PTCP) secondary to the effects of ethylenediaminetetraacetic acid (EDTA) has been noted in horses and pigs and should be considered in dogs with moderate thrombocytopenia and no clinical bleeding tendency. This type of pseudothrombocytopenia is not a pathological process by itself, but it can be clinically significant if diagnostics and medical treatments are initiated based on the reported thrombocytopenia. Platelet clumping occurs with EDTA-dependent PTCP, resulting in inaccurate hematology analyzer platelet concentrations. A nontraumatic venipuncture may be sufficient to obtain an accurate platelet count. However, rare cases in the dog may require blood drawn into a different anticoagulant, such as sodium citrate, to help discriminate a true thrombocytopenia from PTCP.
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March/April 2008
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March 01 2008
Pseudothrombocytopenia Secondary to the Effects of EDTA in a Dog
Tamara B. Wills, DVM, MS, Diplomate ACVP;
Tamara B. Wills, DVM, MS, Diplomate ACVP
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, P.O. Box 646610, Pullman, Washington 99164-6610
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K. Jane Wardrop, DVM, MS, Diplomate ACVP
K. Jane Wardrop, DVM, MS, Diplomate ACVP
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, P.O. Box 646610, Pullman, Washington 99164-6610
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J Am Anim Hosp Assoc (2008) 44 (2): 95–97.
Citation
Tamara B. Wills, K. Jane Wardrop; Pseudothrombocytopenia Secondary to the Effects of EDTA in a Dog. J Am Anim Hosp Assoc 1 March 2008; 44 (2): 95–97. doi: https://doi.org/10.5326/0440095
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