A human kit for cystatin C determination was evaluated for use with canine sera. A reference range was also established. The association between cystatin C and glomerular filtration rate (GFR) was evaluated in 60 dogs with various diseases, by using exogenous creatinine plasma clearance (ECPC) as a measure of GFR. The correlation between cystatin C and ECPC (correlation coefficient [r] = −0.630; P<0.001) was stronger than the correlation between serum creatinine and ECPC (r = −0.572; P<0.001). Nonrenal diseases (e.g., neoplasia, infection) did not influence serum cystatin C concentration. Test sensitivity was significantly better (P<0.001) for cystatin C (76%) than for creatinine (65%). Specificities for the two tests were 87% and 91%, respectively.
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May/June 2008
UROLOGY|
May 01 2008
Utility of Serum Cystatin C as a Clinical Measure of Renal Function in Dogs
Astrid Wehner, DVM;
Astrid Wehner, DVM
Department of Small Animal Internal Medicine, Faculty of Veterinary Medicine, Ludwig Maximilians University Munich, Munich, Germany 80539
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Katrin Hartmann, Dr. med. vet., Diplomate ECVIM-CA;
Katrin Hartmann, Dr. med. vet., Diplomate ECVIM-CA
Department of Small Animal Internal Medicine, Faculty of Veterinary Medicine, Ludwig Maximilians University Munich, Munich, Germany 80539
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Johannes Hirschberger, Dr. med. vet., Diplomate ECVIM-CA (Internal Medicine, Oncology)
Johannes Hirschberger, Dr. med. vet., Diplomate ECVIM-CA (Internal Medicine, Oncology)
Department of Small Animal Internal Medicine, Faculty of Veterinary Medicine, Ludwig Maximilians University Munich, Munich, Germany 80539
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J Am Anim Hosp Assoc (2008) 44 (3): 131–138.
Citation
Astrid Wehner, Katrin Hartmann, Johannes Hirschberger; Utility of Serum Cystatin C as a Clinical Measure of Renal Function in Dogs. J Am Anim Hosp Assoc 1 May 2008; 44 (3): 131–138. doi: https://doi.org/10.5326/0440131
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