A 5-year-old, spayed female cat was referred because of a mass in the cranial mediastinum noted on thoracic radiographs. A thymoma was diagnosed following ultrasound and biopsy of the mass. Treatment was initiated with coarse-fraction radiation therapy using external-beam therapy (four fractions of 5 Gy). The mass responded, but granulocytopenia developed. Bone marrow examination showed a myeloid to erythroid ratio of approximately 1:1, with a left shift within the myeloid line. These findings, as well as the lack of toxic changes within the peripheral blood neutrophils, suggested immune-mediated destruction of peripheral granulocytes. Immune suppression with prednisone and cyclosporine was instituted. After 7 weeks, the neutrophil count returned to normal. The tumor was removed, and cyclosporine was reduced and eventually discontinued 3 weeks postsurgery.
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July/August 2008
Case Reports|
July 01 2008
Granulocytopenia Associated With Thymoma in a Domestic Shorthaired Cat
Janean L. Fidel, MS, DVM, Diplomate ACVR, Diplomate ACVIM;
Janean L. Fidel, MS, DVM, Diplomate ACVR, Diplomate ACVIM
Departments of Veterinary Clinical Sciences (Fidel, Pargass, Holmes) and Veterinary Microbiology and Pathology (Dark), College of Veterinary Medicine, Washington State University, Pullman, Washington 99164-6610
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Indira S. Pargass, DVM;
Indira S. Pargass, DVM
Departments of Veterinary Clinical Sciences (Fidel, Pargass, Holmes) and Veterinary Microbiology and Pathology (Dark), College of Veterinary Medicine, Washington State University, Pullman, Washington 99164-6610
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Michael J. Dark, DVM;
Michael J. Dark, DVM
Departments of Veterinary Clinical Sciences (Fidel, Pargass, Holmes) and Veterinary Microbiology and Pathology (Dark), College of Veterinary Medicine, Washington State University, Pullman, Washington 99164-6610
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Shannon P. Holmes, MS, DVM
Shannon P. Holmes, MS, DVM
Departments of Veterinary Clinical Sciences (Fidel, Pargass, Holmes) and Veterinary Microbiology and Pathology (Dark), College of Veterinary Medicine, Washington State University, Pullman, Washington 99164-6610
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J Am Anim Hosp Assoc (2008) 44 (4): 210–217.
Citation
Janean L. Fidel, Indira S. Pargass, Michael J. Dark, Shannon P. Holmes; Granulocytopenia Associated With Thymoma in a Domestic Shorthaired Cat. J Am Anim Hosp Assoc 1 July 2008; 44 (4): 210–217. doi: https://doi.org/10.5326/0440210
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