Survival following amputation and administration of single-agent carboplatin for treatment of appendicular osteosarcoma (OSA) in dogs was retrospectively examined. Records of 155 dogs with appendicular OSA treated with amputation and single-agent carboplatin were included from 14 centers. Any carboplatin dosage, number of doses, and protocol schedule were eligible for inclusion. The median disease-free interval (DFI) was 256 days. The median overall survival time was 307 days. Similar prognostic survival factors were identified in this study as reported in prior studies of canine appendicular OSA. Median DFI and survival were comparable to those reported in the original Bergman et al publication. Carboplatin treatment improves the survival probability in dogs with appendicular OSA compared to amputation alone and remains an acceptable alternative to adjuvant treatment with cisplatin.
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January/February 2009
Oncology (Appendicular Osteosarcoma)|
January 01 2009
Use of Single-Agent Carboplatin as Adjuvant or Neoadjuvant Therapy in Conjunction With Amputation for Appendicular Osteosarcoma in Dogs
Brenda Phillips, DVM, Diplomate ACVIM (Oncology);
Brenda Phillips, DVM, Diplomate ACVIM (Oncology)
Veterinary Specialty Hospital of San Diego (Phillips), 1733 Nautilus Street, La Jolla, California 92037
The Animal Cancer Center (Powers, Dernell), Colorado State University, 300 West Drake Road, Fort Collins, Colorado 80526
Australian Animal Cancer Foundation (Straw), Brisbane Veterinary Specialist Centre, Corner of Keong and Old Northern Roads, Albany Creek, 4035, Queensland, Australia
Comparative Oncology Program (Khanna), Center for Cancer Research, 37 Convent Drive, Room 2144, Building 37, Bethesda, Maryland 20892
GSH Biomedical Consulting (Hogge), 1733 Nautilus Street, La Jolla, California 92037; and the
Department of Medical Sciences (Vail), School of Veterinary Medicine and The Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin- Madison, 2015 Linden Drive West, Madison, Wisconsin 53706
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Barbara E. Powers, DVM, PhD, Diplomate ACVP;
Barbara E. Powers, DVM, PhD, Diplomate ACVP
Veterinary Specialty Hospital of San Diego (Phillips), 1733 Nautilus Street, La Jolla, California 92037
The Animal Cancer Center (Powers, Dernell), Colorado State University, 300 West Drake Road, Fort Collins, Colorado 80526
Australian Animal Cancer Foundation (Straw), Brisbane Veterinary Specialist Centre, Corner of Keong and Old Northern Roads, Albany Creek, 4035, Queensland, Australia
Comparative Oncology Program (Khanna), Center for Cancer Research, 37 Convent Drive, Room 2144, Building 37, Bethesda, Maryland 20892
GSH Biomedical Consulting (Hogge), 1733 Nautilus Street, La Jolla, California 92037; and the
Department of Medical Sciences (Vail), School of Veterinary Medicine and The Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin- Madison, 2015 Linden Drive West, Madison, Wisconsin 53706
From the
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William S. Dernell, DVM, MS, Diplomate ACVS;
William S. Dernell, DVM, MS, Diplomate ACVS
Veterinary Specialty Hospital of San Diego (Phillips), 1733 Nautilus Street, La Jolla, California 92037
The Animal Cancer Center (Powers, Dernell), Colorado State University, 300 West Drake Road, Fort Collins, Colorado 80526
Australian Animal Cancer Foundation (Straw), Brisbane Veterinary Specialist Centre, Corner of Keong and Old Northern Roads, Albany Creek, 4035, Queensland, Australia
Comparative Oncology Program (Khanna), Center for Cancer Research, 37 Convent Drive, Room 2144, Building 37, Bethesda, Maryland 20892
GSH Biomedical Consulting (Hogge), 1733 Nautilus Street, La Jolla, California 92037; and the
Department of Medical Sciences (Vail), School of Veterinary Medicine and The Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin- Madison, 2015 Linden Drive West, Madison, Wisconsin 53706
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Rod C. Straw, BVSc, Diplomate ACVS;
Rod C. Straw, BVSc, Diplomate ACVS
Veterinary Specialty Hospital of San Diego (Phillips), 1733 Nautilus Street, La Jolla, California 92037
The Animal Cancer Center (Powers, Dernell), Colorado State University, 300 West Drake Road, Fort Collins, Colorado 80526
Australian Animal Cancer Foundation (Straw), Brisbane Veterinary Specialist Centre, Corner of Keong and Old Northern Roads, Albany Creek, 4035, Queensland, Australia
Comparative Oncology Program (Khanna), Center for Cancer Research, 37 Convent Drive, Room 2144, Building 37, Bethesda, Maryland 20892
GSH Biomedical Consulting (Hogge), 1733 Nautilus Street, La Jolla, California 92037; and the
Department of Medical Sciences (Vail), School of Veterinary Medicine and The Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin- Madison, 2015 Linden Drive West, Madison, Wisconsin 53706
From the
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Chand Khanna, DVM, PhD, Diplomate ACVIM (Oncology);
Chand Khanna, DVM, PhD, Diplomate ACVIM (Oncology)
Veterinary Specialty Hospital of San Diego (Phillips), 1733 Nautilus Street, La Jolla, California 92037
The Animal Cancer Center (Powers, Dernell), Colorado State University, 300 West Drake Road, Fort Collins, Colorado 80526
Australian Animal Cancer Foundation (Straw), Brisbane Veterinary Specialist Centre, Corner of Keong and Old Northern Roads, Albany Creek, 4035, Queensland, Australia
Comparative Oncology Program (Khanna), Center for Cancer Research, 37 Convent Drive, Room 2144, Building 37, Bethesda, Maryland 20892
GSH Biomedical Consulting (Hogge), 1733 Nautilus Street, La Jolla, California 92037; and the
Department of Medical Sciences (Vail), School of Veterinary Medicine and The Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin- Madison, 2015 Linden Drive West, Madison, Wisconsin 53706
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Gary S. Hogge, DVM, MS, PhD;
Gary S. Hogge, DVM, MS, PhD
Veterinary Specialty Hospital of San Diego (Phillips), 1733 Nautilus Street, La Jolla, California 92037
The Animal Cancer Center (Powers, Dernell), Colorado State University, 300 West Drake Road, Fort Collins, Colorado 80526
Australian Animal Cancer Foundation (Straw), Brisbane Veterinary Specialist Centre, Corner of Keong and Old Northern Roads, Albany Creek, 4035, Queensland, Australia
Comparative Oncology Program (Khanna), Center for Cancer Research, 37 Convent Drive, Room 2144, Building 37, Bethesda, Maryland 20892
GSH Biomedical Consulting (Hogge), 1733 Nautilus Street, La Jolla, California 92037; and the
Department of Medical Sciences (Vail), School of Veterinary Medicine and The Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin- Madison, 2015 Linden Drive West, Madison, Wisconsin 53706
From the
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David M. Vail, DVM, Diplomate ACVIM (Oncology)
David M. Vail, DVM, Diplomate ACVIM (Oncology)
Veterinary Specialty Hospital of San Diego (Phillips), 1733 Nautilus Street, La Jolla, California 92037
The Animal Cancer Center (Powers, Dernell), Colorado State University, 300 West Drake Road, Fort Collins, Colorado 80526
Australian Animal Cancer Foundation (Straw), Brisbane Veterinary Specialist Centre, Corner of Keong and Old Northern Roads, Albany Creek, 4035, Queensland, Australia
Comparative Oncology Program (Khanna), Center for Cancer Research, 37 Convent Drive, Room 2144, Building 37, Bethesda, Maryland 20892
GSH Biomedical Consulting (Hogge), 1733 Nautilus Street, La Jolla, California 92037; and the
Department of Medical Sciences (Vail), School of Veterinary Medicine and The Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin- Madison, 2015 Linden Drive West, Madison, Wisconsin 53706
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J Am Anim Hosp Assoc (2009) 45 (1): 33–38.
Citation
Brenda Phillips, Barbara E. Powers, William S. Dernell, Rod C. Straw, Chand Khanna, Gary S. Hogge, David M. Vail; Use of Single-Agent Carboplatin as Adjuvant or Neoadjuvant Therapy in Conjunction With Amputation for Appendicular Osteosarcoma in Dogs. J Am Anim Hosp Assoc 1 January 2009; 45 (1): 33–38. doi: https://doi.org/10.5326/0450033
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