Ivermectin is a commonly used veterinary drug that may cause serious problems in overdose situations. A retrospective study was completed, which evaluated canine exposures to ivermectin from 1998 to 2005. The cases were evaluated based on ivermectin dosage, clinical signs seen, signalment of the animal involved, and the potential that the animal could have a p-glycoprotein defect. Results showed that clinical signs may be seen in some animals at doses lower than previously reported. Some dogs may have p-glycoprotein defects or other reasons for increased susceptibility to ivermectin toxicosis. The clinician should be aware that clinical signs may develop even at dosages previously thought to be of little risk (e.g., 0.2 to 2.5 mg/kg in breeds historically considered to have normal p-glycoprotein function).
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May/June 2009
TOXICOLOGY|
May 01 2009
Ivermectin Toxicosis in Dogs: A Retrospective Study
Valentin A Merola, DVM, MS, Diplomate ABT, Diplomate ABVT;
Valentin A Merola, DVM, MS, Diplomate ABT, Diplomate ABVT
ASPCA Animal Poison Control Center, 1717 South Philo Road, Suite 36, Urbana, Illinois 61802
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Safdar Khan, DVM, MS, PhD, Diplomate ABVT;
Safdar Khan, DVM, MS, PhD, Diplomate ABVT
ASPCA Animal Poison Control Center, 1717 South Philo Road, Suite 36, Urbana, Illinois 61802
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Sharon Gwaltney-Brant, DVM, PhD, Diplomate ABT, Diplomate ABVT
Sharon Gwaltney-Brant, DVM, PhD, Diplomate ABT, Diplomate ABVT
ASPCA Animal Poison Control Center, 1717 South Philo Road, Suite 36, Urbana, Illinois 61802
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J Am Anim Hosp Assoc (2009) 45 (3): 106–111.
Citation
Valentin A Merola, Safdar Khan, Sharon Gwaltney-Brant; Ivermectin Toxicosis in Dogs: A Retrospective Study. J Am Anim Hosp Assoc 1 May 2009; 45 (3): 106–111. doi: https://doi.org/10.5326/0450106
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