Fourteen cats received either daily prednisolone (4.4 mg/kg per os [PO]) or dexamethasone (0.55 mg/kg PO) for 56 days. These doses were clinically equipotent. Serum fructosamine and urine glucose were measured on days 0, 28, and 56. Insulin sensitivity, glucose tolerance, and peak insulin secretion were measured in each group prior to and at the end of the courses of glucocorticoid administration. On day 56, the prevalence of glucosuria was significantly greater (P=0.027), and a trend was seen toward greater fructosamine concentrations (P=0.083) in dexamethasone-treated cats compared to prednisolone-treated cats. The results of this pilot study also showed a trend toward a greater decrease in insulin sensitivity (P=0.061) and a significantly lower compensatory increase in insulin secretion (P=0.081) in the dexamethasone-treated cats than in cats administered prednisolone. These preliminary data suggest that dexamethasone exhibits greater diabetogenic effects in cats than equipotent doses of prednisolone. Further study is justified to support this hypothesis.
Skip Nav Destination
Article navigation
September/October 2009
Endocrinology|
September 01 2009
A Pilot Study Comparing the Diabetogenic Effects of Dexamethasone and Prednisolone in Cats
Andrew D. Lowe, DVM, MS, Diplomate ACVD;
Andrew D. Lowe, DVM, MS, Diplomate ACVD
Departments of Veterinary Clinical Medicine (Lowe, Graves, Campbell) and Veterinary Biosciences (Schaeffer), University of Illinois, 1008 West Hazelwood Drive, Urbana, Illinois 61834
From the
Search for other works by this author on:
Thomas K. Graves, DVM, MS, PhD, Diplomate ACVIM;
Thomas K. Graves, DVM, MS, PhD, Diplomate ACVIM
Departments of Veterinary Clinical Medicine (Lowe, Graves, Campbell) and Veterinary Biosciences (Schaeffer), University of Illinois, 1008 West Hazelwood Drive, Urbana, Illinois 61834
From the
Search for other works by this author on:
Karen L. Campbell, DVM, MS, Diplomate ACVD, Diplomate ACVIM;
Karen L. Campbell, DVM, MS, Diplomate ACVD, Diplomate ACVIM
Departments of Veterinary Clinical Medicine (Lowe, Graves, Campbell) and Veterinary Biosciences (Schaeffer), University of Illinois, 1008 West Hazelwood Drive, Urbana, Illinois 61834
From the
Search for other works by this author on:
David J. Schaeffer, PhD
David J. Schaeffer, PhD
Departments of Veterinary Clinical Medicine (Lowe, Graves, Campbell) and Veterinary Biosciences (Schaeffer), University of Illinois, 1008 West Hazelwood Drive, Urbana, Illinois 61834
From the
Search for other works by this author on:
J Am Anim Hosp Assoc (2009) 45 (5): 215–224.
Citation
Andrew D. Lowe, Thomas K. Graves, Karen L. Campbell, David J. Schaeffer; A Pilot Study Comparing the Diabetogenic Effects of Dexamethasone and Prednisolone in Cats. J Am Anim Hosp Assoc 1 September 2009; 45 (5): 215–224. doi: https://doi.org/10.5326/0450215
Download citation file:
Sign in
Don't already have an account? Register
Client Account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Sign in via your Institution
Sign in via your InstitutionCiting articles via
Long-Term Survival of Primary Intracranial Histiocytic Sarcoma Through Surgical Resection and Low-Dose CCNU
Kyosuke Hidari, DVM, Yuya Nakamoto, DVM, PhD, James K. Chambers, DVM, PhD, Kazuyuki Uchida, DVM, PhD, Isao Mori, DVM, Miwa Nakamoto, DVM
Microfilaria in the Urine of a Dog with Concurrent Urinary Bladder Sarcoma
Nicole Schlette, DVM, Erin Burton, DVM, MS, DACVP, Amber Harris, DVM, DACVIM (Internal Medicine), Kendall Langsten, DVM, DACVP, Erik Olson, DVM, PhD, DACVP, Daniel Heinrich, DVM, DACVP
Chronic Myelomonocytic Leukemia with Central Nervous System Involvement in a Dog
Ilaria Tartari, DVM, Fabio Tocco, DVM, Giorgio Cancedda, DVM, Veronica Angioni, DVM, Marco Podda, DVM, Antonella Gallucci, DVM, PhD, DECVN, EBVS
Treatment Outcomes of Canine Orbital Meningiomas in Seven Cases
Akihiro Uno, DVM, Ryota Iwasaki, DVM, PhD, Takashi Mori, DVM, PhD
Transient Hypoadrenocorticism in a 7-Week-Old Kitten
Alba Planas Vintro, BVM, Linda G. Martin, DVM, MS, DACVECC, Cassidy L. Cordon, DVM, Sabrina N. Hoehne, Dr. med. vet., DACVECC, DECVECC, Elizabeth B. Davidow, DVM, DACVECC