Acquired laryngeal paralysis (LP) is an important cause of upper airway obstruction in dogs. We hypothesize that LP may be part of a generalized polyneuropathy complex. Electro-diagnostic studies were performed in six dogs, and histopathological studies of muscle and nerve biopsies were obtained from 11 dogs diagnosed with acquired LP. Abnormalities in electrodiagnostic procedures were consistent with a generalized polyneuropathy. Loss of large-caliber nerve fibers and axonal degeneration were identified in nerve biopsies, and neurogenic atrophy was observed in muscle specimens. Abnormalities in electrodiagnostic studies and histopathology provide evidence that LP may be part of a generalized polyneuropathy. Establishing a diagnosis of a more involved disease process is relevant for long-term prognosis.
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May/June 2010
Case Series: Respiratory Diseases|
May 01 2010
Histopathological Confirmation of Polyneuropathy in 11 Dogs With Laryngeal Paralysis
Kelley M. Thieman, DVM, MS;
Kelley M. Thieman, DVM, MS
Department of Small Animal Clinical Sciences (Thieman, Krahwinkel, Sims), College of Veterinary Medicine, The University of Tennessee, 2407 River Drive, Knoxville, Tennessee 37996; and the
Comparative Neuromuscular Laboratory (Shelton), the Department of Pathology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093
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D.J. Krahwinkel, DVM, MS, Diplomate ACVS, Diplomate ACVA, Diplomate ACVECC;
D.J. Krahwinkel, DVM, MS, Diplomate ACVS, Diplomate ACVA, Diplomate ACVECC
Department of Small Animal Clinical Sciences (Thieman, Krahwinkel, Sims), College of Veterinary Medicine, The University of Tennessee, 2407 River Drive, Knoxville, Tennessee 37996; and the
Comparative Neuromuscular Laboratory (Shelton), the Department of Pathology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093
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Michael H. Sims, PhD;
Michael H. Sims, PhD
Department of Small Animal Clinical Sciences (Thieman, Krahwinkel, Sims), College of Veterinary Medicine, The University of Tennessee, 2407 River Drive, Knoxville, Tennessee 37996; and the
Comparative Neuromuscular Laboratory (Shelton), the Department of Pathology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093
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G. Diane Shelton, DVM, PhD
G. Diane Shelton, DVM, PhD
Department of Small Animal Clinical Sciences (Thieman, Krahwinkel, Sims), College of Veterinary Medicine, The University of Tennessee, 2407 River Drive, Knoxville, Tennessee 37996; and the
Comparative Neuromuscular Laboratory (Shelton), the Department of Pathology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093
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J Am Anim Hosp Assoc (2010) 46 (3): 161–167.
Citation
Kelley M. Thieman, D.J. Krahwinkel, Michael H. Sims, G. Diane Shelton; Histopathological Confirmation of Polyneuropathy in 11 Dogs With Laryngeal Paralysis. J Am Anim Hosp Assoc 1 May 2010; 46 (3): 161–167. doi: https://doi.org/10.5326/0460161
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